Basic information
- Name:
6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,sodium salt (1:1), (3R,5S,6E)-
- Superlist Name:
- Cerivastatin sodium
- CAS No.:
143201-11-0
- Molecular Structure:
![Molecular Structure of 143201-11-0 (6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,sodium salt (1:1), (3R,5S,6E)-)](http://www.lookchem.com/300w/2010/0618/143201-11-0.jpg)
- Formula:
- C26H33FNNaO5
- Molecular Weight:
- 481.54
- Synonyms:
- 6-Heptenoicacid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,monosodium salt, (3R,5S,6E)- (9CI);6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,monosodium salt, [S-[R*,S*-(E)]]-;BAY-w 6228;Baycol;Cerivastatin sodium;Lipobay;Rivastatin;
- Melting Point:
- 197-199°C
- Boiling Point:
- 646.3 °C at 760 mmHg
- Flash Point:
- 344.7 °C
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Chemistry
Molecular Formula: C26H33FNNaO5
Molar mass: 481.5321 g/mol
Flash Point: 344.7 °C
Boiling Point: 646.3 °C at 760 mmHg
Vapour Pressure: 1.37E-17 mmHg at 25°C
Appearance: Solid
Product categories of Cerivastatin sodium (143201-11-0): Inhibitors;Pharmaceuticals
Structure of Cerivastatin sodium (143201-11-0):
H-Bond Donor: 2
H-Bond Acceptor: 7
Systematic Name: Sodium (E,3R,5S)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl]-3,5-dihydroxy-hept-6-enoate
SMILES: [Na+].[O-]C(=O)C[C@H](O)C[C@H](O)/C=C/c1c(nc(c(c1c2ccc(F)cc2)COC)C(C)C)C(C)C
InChI: InChI=1/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1
InChIKey: GPUADMRJQVPIAS-QYZWXYILBX
Std. InChI: InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1
Std. InChIKey: GPUADMRJQVPIAS-QCVDVZFFSA-M
Uses
Cerivastatin sodium (143201-11-0) can be used for intermediate, and also can be used as a competitive inhibitor of HMG-CoA reductase .
Toxicity Data With Reference
| 1. | orl-rat LD50:416 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),402. | ||
| 2. | orl-mus LD50:416 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),402. | ||
| 3. | ivn-mus LD50:221 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),402. | ||
| 4. | orl-dog LDLo:32 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),402. |
Safety Profile
A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and F−.
Specification
Cerivastatin sodium (143201-11-0) is a fine chemical and it's also can be called Rivastatin ; cerivastatin ; Baycol ; Bay w 6228 ; Lipobay ; (3R,5S,6E)-7-(4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt .