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 Gutknecht Pyrazine Synthesis
  • Gutknecht Pyrazine Synthesis
  • Gutknecht Pyrazine Synthesis

    H. Gutknecht, Ber. 12, 2290 (1879); 13, 1116 (1880).

    Cyclization of α-amino ketones, produced by reduction of isonitroso ketones to yield the dihydropyrazines which are dehydrogenated with mercury(I) oxide or copper(II) sulfate, or sometimes with atmospheric oxygen:



    I. J. Krems, P. E. Spoerri, Chem. Rev. 40, 291 (1947); Y. T. Pratt, Heterocyclic Compounds 6, 379, 385 (1957).

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