Ruzicka Large Ring Synthesis

L. Ruzicka et al., Helv. Chim. Acta 9, 249, 339, 389, 499 (1926).

Formation of large ring alicyclic ketones from dicarboxylic acids by thermal decomposition of salts with metals of the second and fourth groups of the periodic table (Ca, Th, Ce):



L. Ruzicka, Chem. & Ind. (London) 54, 2 (1935); H. Gilman, Organic Chemistry vol. 1 (New York, 1943) p 78; K. Ziegler, Houben-Weyl 4/2, 754 (1955). Cf. Blanc Reaction.