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 Sandmeyer Isonitrosoacetanilide Isatin Synthesis
  • Sandmeyer Isonitrosoacetanilide Isatin Synthesis
  • Sandmeyer Isonitrosoacetanilide Isatin Synthesis

    T. Sandmeyer, Helv. Chim. Acta 2, 234 (1919).

    Formation of isonitrosoacetodiphenylamidine by condensation of chloral hydrate, hydroxylamine and aniline, cyclization with concentrated sulfuric acid, and quantitative hydrolysis to isatin on dilution:



    J. Martinet, P. Cousset, Compt. Rend. 172, 1234 (1921); C. Hollins, The Synthesis of Ring Compounds (London, 1924) p 103; C. S. Marvel, G. S. Hiers, Org. Syn. coll. vol. I, 327 (1943); P. L. Julian et al., Heterocyclic Compounds 3, 208 (1952); F. E. Sheibley, J. S. McNulty, J. Org. Chem. 21, 171 (1956); O. Bayer, W. Eckert, Houben-Weyl 7/4, 14 (1968); S. J. Garden et al., Tetrahedron Letters 38, 1501 (1997). Cf. Sandmeyer Diphenylurea Isatin Synthesis.


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