- Acepromazine
-
Acepromazine (brand name Acezine 2), with its CAS registry number , has its IUPAC name of 1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one. This chemical belongs to the classes of s
Following are the detailed information of Acepromazine:
1). Indication of Acepromazine: Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
2). Pharmacodynamics of Acepromazine: Acepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
3). Mechanism of action: Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Prev: Aceprometazine
Next: Acenocoumarol - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 123-08-0 p-Hydroxybenzaldehyde
- 4039-32-1 Lithium bis(trimethylsilyl)amide
- 86401-80-1 16alpha-Hydroxyprednisonlone acetate
- 41340-25-4 Etodolac
- 503155-67-7 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide
- 64-18-6 Formic acid
- 606-04-2 Pamabrom
- 102-32-9 DOPAC
- 305808-21-3 TRIETHYLENETETRAMINE HYDRATE 98
- 1113-59-3 Propanoic acid,3-bromo-2-oxo-
- 25496-92-8 Sucrose oleate
- 8007-46-3 Thyme Oil