Pipequaline (CAS NO.: ), with other name of 2-Phenyl-4-(2-piperidin-4-ylethyl)quinoline, could be produced through many synthetic methods.

Following is one of the reaction routes:

The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III), which is then reduced with hydrazine at 180 C.