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Chlordiazepoxide hydrochloride

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Name Chlordiazepoxide hydrochloride EINECS
CAS No. 438-41-5 Density g/cm3
Solubility slight

Stability

    Stable. Incompatible with strong oxidizing agents.

Toxicology

    Harmful if swallowed. Possible risk that this material may affect fertility,cause harm to the unborn child, or give rise to ir
Melting Point 212 - 218 C
Formula C16H14 Cl N3 O . Cl H Boiling Point 451°Cat760mmHg
Molecular Weight 336.24 Flash Point 226.6°C
Transport Information Appearance white crystalline powder
Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, distorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquilizer. When heated to decomposition it emits very toxic fumes of HCl and NOx. Risk Codes 22-62-63-68
Molecular Structure Molecular Structure of 438-41-5 (3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, hydrochloride (1:1)) Hazard Symbols
Synonyms

3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride (9CI);3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide,monohydrochloride (6CI,8CI);7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide hydrochloride;A-Poxide; Ansiacal; Benzodiapin; Cebrum; Chlordiazepoxide hydrochloride;Chlordiazepoxide monohydrochloride; Chlorodiazepoxide hydrochloride; Contol;Corax; Disarim; Equibral; Labican; Lentotran; Librium; Librium hydrochloride;Methaminodiazepoxide hydrochloride; NSC 115748; OCM; Psichial; Psicoterina; Reliberan;Ro 5-0690; SK-Lygen; Seren Vita; Viansin

 

Chemistry

Product Name: Methaminodiazepoxide hydrochloride (CAS NO.438-41-5)


Molecular Formula: C16H15Cl2N3O
Molecular Weight: 336.22g/mol
Mol File: 438-41-5.mol
Einecs: 207-117-8
Appearance: White crystalline powder
Boiling point: 566.6 °C at 760 mmHg
Flash Point: 296.5 °C
Water Solubility: Slight
Stability: Stable. Incompatible with strong oxidizing agents.
Enthalpy of Vaporization: 86.66 kJ/mol
Vapour Pressure: 3.78E-13 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 4

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1gm/kg (1000mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
man TDLo oral 39mg/kg/30D-I (39mg/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: ATAXIA
Clinical Toxicology. Vol. 2, Pg. 5, 1969.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Journal of Medicinal Chemistry. Vol. 14, Pg. 1106, 1971.
mouse LD50 intravenous 95mg/kg (95mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 163, 1960.
mouse LD50 oral 530mg/kg (530mg/kg)   "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973Vol. -, Pg. 39, 1973.
mouse LD50 parenteral 700mg/kg (700mg/kg)   United States Patent Document. Vol. #4371536,
mouse LD50 subcutaneous 530mg/kg (530mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
quail LD50 oral 1gm/kg (1000mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 intravenous 36mg/kg (36mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rabbit LD50 oral 590mg/kg (590mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat LD50 intraperitoneal 276mg/kg (276mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat LD50 intravenous 165mg/kg (165mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
rat LD50 oral 537mg/kg (537mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
women TDLo oral 8400ug/kg/2W- (8.4mg/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Clinical Toxicology. Vol. 2, Pg. 5, 1969.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, distorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquilizer. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Safety Information of Methaminodiazepoxide hydrochloride (CAS NO.438-41-5):
Hazard Codes: Xn
Risk Statements: 22-62-63-68 
22:  Harmful if swallowed
62:  Possible risk of impaired fertility 
63:  Possible risk of harm to the unborn child 
68:  Possible risk of irreversible effects 
Safety Statements: 22-36/37
22:  Do not breathe dust
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 

Specification

 Methaminodiazepoxide hydrochloride ,its CAS NO. is 438-41-5,the synonyms is 3H-1,4-benzodiazepin-2-amine,7-chloro-n-methyl-5-phenyl-,4-oxide,monohydro ; 3H-1,4-benzodiazepine,7-chloro-2-methylamino-5-phenyl-,4-oxide,monohydrochlo ; Ansiacal;a-poxide ; Benzodiapin ; Calmoden ; Cebrum ; Chlordiazachel .

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