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Cas Database |
| Name |
Clindamycin phosphate |
EINECS | 246-433-0 |
| CAS No. | 24729-96-2 | Density | 1.41 g/cm3 |
| PSA | 183.90000 | LogP | 0.83530 |
| Solubility | Soluble in water | Melting Point |
114 °C |
| Formula | C18H34ClN2O8PS | Boiling Point | 159°C |
| Molecular Weight | 504.969 | Flash Point | N/A |
| Transport Information | N/A | Appearance | White solid |
| Safety | 36-26 | Risk Codes | 22-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi, Xn
|
| Synonyms |
U 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate; |
Article Data | 6 |
Clindamycin phosphate Synthetic route
- 24729-96-2
clindamycin phosphate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In water at 50 - 55℃; for 10h; | 96.15% |
- 24729-96-2
clindamycin phosphate
| Conditions | Yield |
|---|---|
| In water at 20℃; for 8h; Temperature; Acidic conditions; Green chemistry; | 92% |
- 24729-96-2
clindamycin phosphate
| Conditions | Yield |
|---|---|
| Stage #1: C35H50ClN2O8PS With palladium 10% on activated carbon; hydrogen In methanol at 20 - 30℃; under 2585.81 Torr; for 15h; Stage #2: With hydrogenchloride at 60 - 70℃; for 24h; Time; | 84.2% |
- 21462-39-5
clindamycin hydrochloride
- 24729-96-2
clindamycin phosphate
- 859-18-7
lincomycin hydrochloride
- 24729-96-2
clindamycin phosphate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: phosgene / chloroform; N,N-dimethyl-formamide / 2 h / 5 - 71 °C / Large scale 1.2: 10 °C / Alkaline conditions; Large scale 2.1: toluene-4-sulfonic acid / acetone / 6 h / 35 °C / Large scale 3.1: triethylamine; trichlorophosphate; 1H-imidazole / acetone / 4 h / 22 °C / Large scale 3.2: 30 °C / Large scale View Scheme |
- 24729-96-2
clindamycin phosphate
| Conditions | Yield |
|---|---|
| Stage #1: C21H37ClN2O5S With 1H-imidazole; triethylamine; trichlorophosphate In acetone at 22℃; for 4h; Large scale; Stage #2: With water In acetone at 30℃; Temperature; Reagent/catalyst; Large scale; |
Clindamycin phosphate Chemical Properties
IUPAC Name: [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-Chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
Synonyms of Clindamycin-2-phosphate (CAS NO.24729-96-2): 2-(Dihydrogenphosphate ; 7(S)-Chloro-7-deoxylincomycin2-phosphate ; Ceocinphosphate ; Dalacinp ; Clindamycin-2-dihydrogenphosphat ; Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside 2-(dihydrogen phosphate)
CAS NO: 24729-96-2
Molecular Formula:C18H34ClN2O8PS
Molecular Weight:505.02
Molecular Structure: 
EINECS:246-433-0
H bond acceptors: 10
H bond donors: 5
Freely Rotating Bonds: 11
Polar Surface Area: 131.11 Å2
Index of Refraction: 1.577
Molar Refractivity: 117.96 cm3
Molar Volume: 355.9 cm3
Surface Tension: 63.5 dyne/cm
Density:1.41 g/cm3
Melting Point:114 °C
Solubility: Soluble in water
Storage temp: 2-8°C
Appearance: White solid
Stability: Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
Product Categories of Clindamycin-2-phosphate (CAS NO.24729-96-2): Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);API's
Clindamycin phosphate Uses
Clindamycin-2-phosphate (CAS NO.24729-96-2) is used as pharmaceutical intermediate.
Clindamycin phosphate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 1100mg/kg (1100mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| mouse | LD50 | intraperitoneal | 784mg/kg (784mg/kg) | Drugs under Experimental and Clinical Research. Vol. 3, Pg. 79, 1977. | |
| mouse | LD50 | intravenous | 820mg/kg (820mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| mouse | LD50 | oral | 2539mg/kg (2539mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| mouse | LD50 | subcutaneous | 1036mg/kg (1036mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| rat | LD50 | intramuscular | > 3500mg/kg (3500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983. | |
| rat | LD50 | intraperitoneal | 745mg/kg (745mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| rat | LD50 | intravenous | 321mg/kg (321mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| rat | LD50 | oral | 1832mg/kg (1832mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology and Applied Pharmacology. Vol. 27, Pg. 308, 1974. |
| rat | LD50 | subcutaneous | 3861mg/kg (3861mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| women | TDLo | intravenous | 12mg/kg (12mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Southern Medical Journal. Vol. 75, Pg. 768, 1982. |
Clindamycin phosphate Safety Profile
Safety Information of Clindamycin-2-phosphate (CAS NO.24729-96-2):
Hazard Codes: 
Xn,Xi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GF2625000
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human systemic effects by intravenous route: pulse rate increase, blood pressure lowering. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl−, POx, SOx, and NOx.
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