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Name |
Clinofibrate |
EINECS | 1312995-182-4 |
CAS No. | 30299-08-2 | Density | 1.163 g/cm3 |
PSA | 93.06000 | LogP | 6.20100 |
Solubility | N/A | Melting Point |
143-145°C |
Formula | C28H36O6 | Boiling Point | 619.2 °C at 760 mmHg |
Molecular Weight | 468.59 | Flash Point | 200.3 °C |
Transport Information | N/A | Appearance | White crystalline powder |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane;Butanoic acid,2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-;Lipoclin;S 8527; |
Article Data | 3 |
IUPAC: 2-[4-[1-[4-(1-Hydroxy-2-methyl-1-oxobutan-2-yl)oxyphenyl]cyclohexyl]phenoxy]-2-methylbutanoic acid
Molecular Formula: C28H36O6
Molecular Weight: 468.58 g/mol
Molecule structure of Clinofibrate (CAS NO.30299-08-2):
Density: 1.163 g/cm3
Flash Point: 198.1 °C
Enthalpy of Vaporization: 95.77 kJ/mol
Boiling Point: 613.8 °C at 760 mmHg
Vapour Pressure: 6.38E-16 mmHg at 25 °C
Index of Refraction: 1.558
Molar Refractivity: 129.94 cm3
Molar Volume: 402.6 cm3
Surface Tension: 47.4 dyne/cm
XLogP3-AA: 7.5
H-Bond Donor: 2
H-Bond Acceptor: 6
Rotatable Bond Count: 10
Exact Mass: 468.251189
MonoIsotopic Mass: 468.251189
Topological Polar Surface Area: 93.1
Heavy Atom Count: 34
Canonical SMILES: CCC(C)(C(=O)O)OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)OC(C)(CC)C(=O)O
InChI: InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
InChIKey: BMOVQUBVGICXQN-UHFFFAOYSA-N
Product Categories: API
Clinofibrate (CAS NO.30299-08-2) is lipid-lowering drugs, not only inhibit the occurrence of hyperlipidemia, but also significantly reduce levels of plasma endothelin.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 230mg/kg (230mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1553, 1981. |
mouse | LD50 | intravenous | 150mg/kg (150mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
mouse | LD50 | oral | 1600mg/kg (1600mg/kg) | Drugs in Japan Vol. 6, Pg. 219, 1982. | |
mouse | LD50 | subcutaneous | 350mg/kg (350mg/kg) | Drugs in Japan Vol. 6, Pg. 219, 1982. | |
rat | LD50 | intraperitoneal | 205mg/kg (205mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
rat | LD50 | intravenous | > 150mg/kg (150mg/kg) | Drugs in Japan Vol. 6, Pg. 219, 1982. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 219, 1982. | |
rat | LD50 | subcutaneous | 1930mg/kg (1930mg/kg) | Drugs in Japan Vol. 6, Pg. 219, 1982. |
Clinofibrate (CAS NO.30299-08-2) is also named as 2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutyric acid ; 2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methylbutanoic acid) ; 2,2'-(Cyclohexylidenebis(p-phenyleneoxy))bis(2-
methylbutyric acid) ; 2,2'-Cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyric acid) ; 2,2'-Dimethyl-2,2'-(4,4'-
cyclohexylidendiphenoxy)dibuttersaeure ; BRN 2230067 ; Clinofibrato ; Clinofibrato [INN-Spanish] ; Clinofibratum ; Clinofibratum [INN-Latin] ; Lipoclin ; S 8527 ; UNII-0374EZJ8CU . Clinofibrate (CAS NO.30299-08-2) is a fibrate.