Welcome to LookChem.com Sign In | Join Free   Post buying lead  Chemical Tools
Post Buying Lead

Basic information

  • Name:

  • 2H-1,4-Benzodiazepin-2-one,5-(2-chlorophenyl)-1,3-dihydro-7-nitro-

  • Superlist Name:
  • Clonazepam
  • CAS No.:

  • 1622-61-3

  • Formula:
  • C15H10ClN3O3
  • Synonyms:
  • 2H-1,4-Benzodiazepin-2-one,5-(o-chlorophenyl)-1,3-dihydro-7-nitro- (7CI,8CI);Lonazep;NSC 179913;Rivotril;Ro 5-4023;Kenoket;Iktorivil;Clonopin;5-(6-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one;7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;Antilepsin;Apetryl;Clonex;

Related products

Other Products

Home > Hot Product_List > Clonazepam
Notice:Certain products cannot be sold because they are prohibited on LookChem.com.- e.g. API such as Morphine cannot be sold.

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Supplier of this product? Please post selling leads now!

Chemistry


IUPAC Name: 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
Molecular Formula: C15H10ClN3O3
Molecular Weight: 315.71 g/mol
EINECS: 216-596-2
Classification Code: Anticonvulsant; Anticonvulsants; Central Nervous System Agents; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Human Data; Mutation data; Neurotransmitter Agents; Reproductive Effect
Melting Point: 236.5-238.5 °C
storage temp.: 2-8 °C
Index of Refraction: 1.701
Molar Refractivity: 81.24 cm3
Molar Volume: 209.9 cm3
Surface Tension: 61.8 dyne/cm
Density: 1.5 g/cm3
Flash Point: 271 °C
Enthalpy of Vaporization: 79.84 kJ/mol
Boiling Point: 524.5 °C at 760 mmHg
Vapour Pressure of Clonazepam (CAS NO.1622-61-3): 4.27E-11 mmHg at 25 °C

Uses

 Clonazepam (CAS NO.1622-61-3) is used as a muscle relaxant and a sedative for sleep (Off Label Use).

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1329ug/kg/31D (1.329mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED American Journal of Gastroenterology. Vol. 83, Pg. 576, 1988.
man TDLo oral 21mg/kg/26W-I (21mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS Postgraduate Medical Journal. Vol. 63, Pg. 311, 1987.
mouse LD50 intraperitoneal 13300mg/kg (13300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse LD50 intravenous > 18mg/kg (18mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse LD50 oral 2gm/kg (2000mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 35, Pg. 77, 1983.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.
rat LD50 intraperitoneal 14200mg/kg (14200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
rat LD50 oral > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.

Safety Profile

Hazard Codes: FlammableF,ToxicT
Risk Statements: 11-23/24/25-39/23/24/25 
R11:Highly flammable. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R39:Danger of very serious irreversible effects.
Safety Statements: 7-16-36/37-45-24/25-22 
S7:Keep container tightly closed. 
S16:Keep away from sources of ignition. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S24/25:Avoid contact with skin and eyes.
S22:Do not breathe dust.
RIDADR: UN 1230 3/PG 2
WGK Germany: 2
RTECS: DF2100000
HazardClass: 6.1(b)
PackingGroup: III

Specification

  Clonazepam (CAS NO.1622-61-3), its Synonyms are 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one ; 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- ; 2H-1,4-Benzodiazepin-2-one, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- ; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one ; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one ; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one . It is tan solid.

©2008 LookChem.com,License:ICP NO.：Zhejiang10014259

[Hangzhou]86-571-85317600,85317603,85317620