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Codeine sulfate

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Name

Codeine sulfate

EINECS N/A
CAS No. 1420-53-7 Density g/cm3
PSA 124.91000 LogP 1.86700
Solubility N/A Melting Point N/A
Formula C36H42N2O6•O4S Boiling Point 462°Cat760mmHg
Molecular Weight 694.86 Flash Point 233.2°C
Transport Information N/A Appearance N/A
Safety Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An addictive, narcotic drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also CODEINE. Risk Codes 22
Molecular Structure Molecular Structure of 1420-53-7 (3-METHYLMORPHINE SULFATE SALT) Hazard Symbols
Synonyms

CODEINE SULFATE;CODEINE SULPHATE;DICODEINE SULFATE;3-METHYLMORPHINE SULFATE SALT;CODEINE SULFATE OPIATE ANALGESIC, ANT;Codeine sulfate salt

 

Codeine sulfate Chemical Properties

Product Name: Codeine sulfate
Synonyms of Codeine sulfate (CAS NO.1420-53-7) : (5alpha,6alpha)-3-Methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-ol sulfate (1:1) ; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, sulfate (1:1) (salt) ; Codeine sulphate ; Copavin
CAS NO:1420-53-7
Molecular Formula:C18H23NO7S
Molecular Weight :397.4427
Molecular Structure :
Flash Point: 233.2 °C
Enthalpy of Vaporization: 76.18 kJ/mol
Boiling Point: 462 °C at 760 mmHg
Vapour Pressure: 2.47E-09 mmHg at 25°C

Codeine sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 143mg/kg (143mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmaceutical Sciences. Vol. 63, Pg. 451, 1974.
mouse LD50 intravenous 68mg/kg (68mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 332, 1961.
mouse LD50 oral 395mg/kg (395mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 332, 1961.
mouse LD50 subcutaneous 183mg/kg (183mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 332, 1961.
rat LD50 intraperitoneal 107mg/kg (107mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
Toxicology. Vol. 14, Pg. 217, 1979.
rat LD50 intravenous 55mg/kg (55mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 332, 1961.
rat LD50 oral 430mg/kg (430mg/kg) BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 48, 1959.
rat LD50 subcutaneous 332mg/kg (332mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 332, 1961.

Codeine sulfate Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An addictive, narcotic drug. When Codeine sulfate (CAS NO.1420-53-7) is heated to decomposition it emits very toxic fumes of NOx and SOx. See also CODEINE.

Hazard Codes HarmfulXn
Risk Statements 22
R22: Codeine sulfate (CAS NO.1420-53-7) is harmful if swallowed.
RTECS QD1400000