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Colistin sulfate

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Name

Colistin sulfate

EINECS 215-034-3
CAS No. 1264-72-8 Density ==
PSA 573.64000 LogP 1.96320
Solubility Soluble in water Melting Point 200-220 °C
Formula 2(C52H98N16O13).5(H2SO4) Boiling Point 1537.3 °C at 760 mmHg
Molecular Weight 1253.51000 Flash Point 883.5 °C
Transport Information N/A Appearance Powder
Safety 45 Risk Codes 25
Molecular Structure Molecular Structure of 1264-72-8 (Colistin sulfate) Hazard Symbols ToxicT
Synonyms

NSC 248648;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;Belcomycin;Polymyxin E sulfate;Colomycin; Colomycin syrup;

 

Colistin sulfate Standards and Recommendations

Enterprise Standard:

Content≥98.0%
 

Colistin sulfate Specification

The Colistin sulfate, with the CAS registry number 408332-79-6, is also known as Belcomycin. It belongs to the product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries. Its EINECS number is 215-034-3. What's more, its systematic name is N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate. Its classification code is Antibacterial. It is a cyclic polypeptide antibiotic from Bacillus colistinus. Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used as topical creams, powders, and otic solutions. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides. It should be ensured that the workshop is well ventilated or equipped with exhaust devices. 

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic if swallowed. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
(2)Smiles: N1[C@H](C(NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C1=O)CCN)=O)CCN)CC(C)C)CC(C)C)CCN)NC([C@@H](NC(=O)[C@H]([C@H](O)C)NC([C@@H](NC(=O)CCCC[C@@H](CC)C)CCN)=O)CCN)=O)=O)[C@H](O)C.S(O)(O)(=O)=O

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 58mg/kg (58mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
mouse LD50 intraperitoneal 21800ug/kg (21.8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
mouse LD50 intravenous 6mg/kg (6mg/kg)   Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.
mouse LD50 oral 793mg/kg (793mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
mouse LD50 subcutaneous 53500ug/kg (53.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
rat LD50 intraperitoneal 10572ug/kg (10.572mg/kg)   Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960.
rat LD50 oral 121mg/kg (121mg/kg)   Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960.
rat LD50 subcutaneous 72200ug/kg (72.2mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 7, 1979.

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