Cresol

Molecular Structure:

Molecular Formula: C₇H₈O
Molecular Weight: 108.1378
IUPAC Name: 4-Methylphenol
Synonyms of Cresol (CAS NO.1319-77-3): Cresol, pure ; Coal tar phenols ; Cresol (isomers and mixture) ; Cresol (mixed isomers) ; Cresol, all isomers ; Cresols ; Cresols / cresylic acid (isomers and mixture) ; Cresols, mixed isomers ; Cresylic acid ; Cresylic acid (isomers and mixture) ; Cresylic acid [UN2022] [Poison] ; Cresylic acid, dephenolized ; Phenol, methyl- ; RCRA waste no. U052 ; UN2022
CAS NO: 1319-77-3
Classification Code: Agricultural Chemical ; Disinfectant ; Fungicide, bactericide, wood preservative ; Human Data ; Insecticide ; Tumor data
Melting point: -1--2°C 
Index of Refraction: 1.545
Molar Refractivity: 32.95 cm³
Molar Volume: 104.1 cm³
Surface Tension: 38.8 dyne/cm
Density: 1.038 g/cm³
Flash Point: 77.1 °C
Enthalpy of Vaporization: 44.47 kJ/mol
Boiling Point: 191 °C at 760 mmHg
Vapour Pressure: 0.379 mmHg at 25°C

 Cresol (CAS NO.1319-77-3) can be used to dissolve other chemicals, as disinfectants and deodorizers, and to make specific chemicals that kill insect pests. It solutions are used as household cleaners and disinfectants, perhaps most famously under the trade name Lysol. It solutions have been used as antiseptics in surgery, but they have been largely displaced in this role by less toxic compounds.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	LDLo	oral	114mg/kg (114mg/kg)	VASCULAR: OTHER CHANGES	"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 404, 1989.
man	TDLo	oral	177mg/kg (177mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA BLOOD: OTHER CHANGES	Canadian Medical Association Journal. Vol. 130, Pg. 1319, 1984.
mouse	LD50	oral	760mg/kg (760mg/kg)		Kyushu Shika Gakkai Zasshi. Journal of the Kyushu Dental Society. Vol. 36, Pg. 932, 1982.
rabbit	LD50	skin	2gm/kg (2000mg/kg)		Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.
rat	LD50	oral	1454mg/kg (1454mg/kg)		National Technical Information Service. Vol. PB214-270,
women	TDLo	oral	700uL/kg (0.7mL/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" BLOOD: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 16, Pg. 667, 1998.

1、RTECS#: CAS# 1319-77-3: GO5950000
2、LD50/LC50: RTECS: CAS# 1319-77-3: Oral, mouse: LD50 = 760 mg/kg;Oral, mouse: LD50 = 860 mg/kg;
Oral, rat: LD50 = 1454 mg/kg;Skin, rabbit: LD50 = 2 gm/kg;Skin, rabbit: LD50 = 200 mg/kg;
3、Carcinogenicity: Cresol - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. 
4、Other: See actual entry in RTECS for complete information.

Hazard Codes of Cresol (CAS NO.1319-77-3): T
Risk Statements: 20-24/25-34-52/53-68 
R20: Harmful by inhalation
R24/25: Toxic in contact with skin and if swallowed 
R34: Causes burns
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R68: Possible risk of irreversible effects
Safety Statements: 26-36/37/39-45-61 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets
RIDADR: UN 2076 6.1/PG 2
WGK Germany: 1
RTECS: GO5950000
F: 8-23 
F 8: Photosensitive
F 23: Sensitive to air
HazardClass: 6.1(a)
PackingGroup: II
A poison by ingestion. Moderately toxic by skin contact. Corrosive to skin and mucous membranes. Systemic poisoning has rarely been reported, but it is possible that absorption may result in damage to the kidneys, liver, and nervous system. The main hazard accompanying its use in industry lies in severe chemical burns and dermatitis.

OSHA PEL: TWA 5 ppm (skin)
ACGIH TLV: TWA 5 ppm
DFG MAK: (all isomers) 5 ppm (22 mg/m³)
NIOSH REL: (Cresol) TWA 10 mg/m³
DOT Classification:  6.1; Label: Poison

For occupational chemical analysis use OSHA: #32 or NIOSH: Cresols, 2001.

 Cresol (CAS NO.1319-77-3) are organic compounds that are methylphenols. They are a widely occurring natural and manufactured group of aromatic organic compounds which are categorized as phenols (sometimes called phenolics). Depending on the temperature, Cresol (CAS NO.1319-77-3) can be solid or liquid because they have melting points not far from room temperature. Like other types of phenols, they are slowly oxidized by long exposure to air and the impurities often give cresols a yellowish to brownish red tint. It have an odor characteristic to that of other simple phenols, reminiscent to some of a "coal tar" smell.
1. Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.  Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
2. Handling and StorageHandling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. 
Storage: Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Corrosives area.