Cyproterone acetate (427-51-0),Cyproterone acetate (427-51-0) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Cyproterone acetate
CAS No.:
427-51-0
Molecular Structure:
Formula:
C₂₄H₂₉ClO₄
Molecular Weight:
416.98
Synonyms:
SH 714;Cyproteron-r acetate;6-Chloro-1beta,2beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate;Cyproteroneacetate;Cyproterone acetate (JAN/USAN);Cyproviron;1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate;6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate;3H-Cyclopropa[1,2]pregna-1,4,6-triene-3, 20-dione, 17- (acetyloxy)-6-chloro-1,2-dihydro-, (1.beta., 2.beta.)-;6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate;17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione;1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate;Cyproterone acetate [USAN:JAN];Cyproterone 17-O-acetate;6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate;SH 80714;3H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate;6-Chloro-17-hydroxy-1.alpha.,2.alpha.-methylenepregna-4, 6-diene-3,20-dione acetate;Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17.alpha.-acetate;1, 2.alpha.-Methylene-6-chloro-(sup 4,6)-pregnadiene-17.alpha.-ol-3, 20-dione 17alpha-acetate;Progesterone, 6-chloro-6-dehydro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17alpha-acetate;3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20- dione,17-(acetyloxy)-6-chloro-1,2-dihydro-,(1a,2a)-;Cyproteron acetate;Cyprosterone acetate;Androcur;6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate;
EINECS:
207-048-3
Density:
1.27 g/cm³
Melting Point:
200-201 °C
Boiling Point:
525.9 °C at 760 mmHg
Flash Point:
177.6 °C
Appearance:
Crystalline solid
Hazard Symbols:
Xn, Xi
Risk Codes:
20/21/22-40-36/37/38
Safety Description:
22-36-26 Details

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Chemistry

Product Name: Cyproterone acetate
Molecular Structure:

Molecular Formula: C₂₄H₂₉ClO₄
Molecular Weight: 416.9377
Synonyms of Cyproterone acetate (CAS NO.427-51-0): 1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate ; 1,2-alpha-Methylene-6-chloro-delta(sup 6)-17-alpha-hydroxyprogesterone acetate ; 1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate ; 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione ; 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- ; 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat ; 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat [German] ; 6-Chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup 6)-progesterone acetate ; 6-Chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesterone acetate ; 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione acetate ; 6-Chloro-1beta,2beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate ; 6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate ; 6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate ; Androcur ; CCRIS 4385 ; Cyprostat ; Cyproteron-R acetate ; Cyproterone 17-O-acetate ; Cyproterone 17alpha-acetate ; Cyproterone acetate ; EINECS 207-048-3 ; HSDB 3592 ; NSC 81430 ; NSC-81430 ; Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-, acetate ; SH 714 ; SH 80714 ; UNII-4KM2BN5JHF
CAS NO: 427-51-0
Classification Code: Androgen antagonists ; Anti-androgen ; Antineoplastic agents ; Contraceptive Agents ; Contraceptive agents, male ; Drug / Therapeutic Agent ; Hormone Antagonists ; Hormones, Hormone Substitutes, and Hormone Antagonists ; Human Data ; Mutation data ; Reproductive Control Agents ; Reproductive Effect ; Tumor data
Melting Point: 200-201°C
Index of Refraction: 1.582
Molar Refractivity: 109.16 cm³
Molar Volume: 327 cm³
Surface Tension: 48.9 dyne/cm
Density: 1.27 g/cm³
Flash Point: 177.6 °C
Enthalpy of Vaporization: 80.01 kJ/mol
Boiling Point: 525.9 °C at 760 mmHg
Vapour Pressure: 3.78E-11 mmHg at 25°C

Uses

Cyproterone acetate (CAS NO.427-51-0) is used in treating of benign prostatauxe and male contraceptive pill.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	171mg/kg/17W- (171mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Israel Journal of Medical Sciences. Vol. 30, Pg. 238, 1994.
man	TDLo	oral	514mg/kg/7W-I (514mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" LIVER: LIVER FUNCTION TESTS IMPAIRED	Australian and New Zealand Journal of Medicine. Vol. 26, Pg. 724, 1996.
mouse	LD50	intraperitoneal	3300mg/kg (3300mg/kg)		Drugs in Japan Vol. 6, Pg. APP-4, 1982.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-4, 1982.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-4, 1982.
rat	LD50	intraperitoneal	565mg/kg (565mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-4, 1982.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-4, 1982.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Safety Information of Cyproterone acetate (CAS NO.427-51-0):
Hazard Codes:Xn,Xi
Risk Statements:20/21/22-40-36/37/38
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
40:Limited evidence of a carcinogenic effect
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-36-26
22:Do not breathe dust
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3
RTECS:GZ2230000
Hazardous Substances Data:427-51-0(Hazardous Substances Data)
Questionable carcinogen with experimental tumorigenic and teratogenic data. Moderately toxic by intraperitoneal route. Human reproductive effects by ingestion and possibly other routes: abnormal spermatogenesis, changes in the testes, epididymis, and sperm duct, impotence, and other paternal effects. Experimental reproductive effects. Mutation data reported. Used as a drug to arrest precocious puberty in children and hirsutism in women. A steroid. When heated to decomposition it emits toxic fumes of Cl⁻.