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Basic information

  • Name:

  • Cyromazine

  • CAS No.:

  • 66215-27-8

  • Formula:
  • C6H10N6
  • Synonyms:
  • 1,3,5-Triazine-2,4,6-triamine,N-cyclopropyl- (9CI);2,4-Diamino-6-(cyclopropylamino)-s-triazine;2-Cyclopropylamino-4,6-diamino-s-triazine;CGA 72662;Citation;Cyclopropylmelamine;

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Chemistry

Molecular structure of Cyromazine (CAS NO.66215-27-8) is:

Product Name: Cyromazine
CAS Registry Number: 66215-27-8
IUPAC Name: 2-N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
Molecular Weight: 166.1838 [g/mol]
Molecular Formula: C6H10N6
XLogP3: -0.2
H-Bond Donor: 3
H-Bond Acceptor: 6 
EINECS: 266-257-8
Melting Point: 223-227 °C(lit.)
Surface Tension: 132.7 dyne/cm
Density: 1.622 g/cm3
Flash Point: 244.5 °C
Enthalpy of Vaporization: 74.52 kJ/mol
Boiling Point: 480.7 °C at 760 mmHg
Vapour Pressure: 2.13E-09 mmHg at 25°C
Product Categories: Fine Chemical & Intermediates;Active Pharmaceutical Ingredients;Insecticide

Uses

In veterinary medicine, Cyromazine (CAS NO.66215-27-8) is used as a ectoparasiticide. Also it can be used as an insecticide and an acaricide.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
domestic animals - goat/sheep LDLo oral 500mg/kg (500mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

BEHAVIORAL: ATAXIA		 National Technical Information Service. Vol. OTS0538005,
duck LD50 oral > 6gm/kg (6000mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C91, 1991.
quail LD50 oral 1785mg/kg (1785mg/kg)   Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat LC50 inhalation > 2720mg/m3/4H (2720mg/m3)   Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat LD50 oral 3387mg/kg (3387mg/kg)   Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat LD50 skin > 3100mg/kg (3100mg/kg)   Pesticide Manual. Vol. 9, Pg. 217, 1991.

Safety Profile

The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) provides a test method for analyzing cyromazine and Melamine in animal tissues in its Chemistry Laboratory Guidebook which "contains test methods used by FSIS Laboratories to support the Agency's inspection program, ensuring that meat, poultry, and egg products are safe, wholesome and accurately labeled." In 1999, in a proposed rule published in the Federal Register regarding cyromazine residue, the United States Environmental Protection Agency (EPA) proposed "remov[ing] Melamine, a metabolite of cyromazine from the tolerance expression since it is no longer considered a residue of concern."
Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XZ1056500

Specification

 Cyromazine , its cas register number is 66215-27-8. It also can be called N-cyclopropyl-1,3,5-triazine-2,4,6-triamine ; 2-Cyclopropylamino-4,6-diamino-s-triazine ; Diamino-6-(cyclopropylamino)-s-triazine ; Cyclopropyl-1,3,5-triazine-2,4,6-triamine ; Cyclopropylmelamine ; Larvadex ; OMS-2014 ; Trigard .It is a crystals.It works by affecting the nervous system of the immature larval stages of certain insects.

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