Basic information
- Name:
Cytisine
- CAS No.:
485-35-8
- Molecular Structure:
- Formula:
- C11H14N2O
- Molecular Weight:
- 190.27
- Deleted CAS:
- 3728-36-7
- Synonyms:
- 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-, (1R)-;Cytisine (6CI,8CI);(-)-Cytisine;Baptitoxin;Baptitoxine;Cytisin;Cytiton;Cytitone;Laburnin;Sophorin;Sophorine;Tabex;Tsitafat;Ulexin;Ulexine;1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-, (1R,5S)-;
- EINECS:
- 207-616-0
- Density:
- 1.24 g/cm3
- Melting Point:
- 154-156 °C(lit.)
- Boiling Point:
- 413 °C at 760 mmHg
- Flash Point:
- 203.6 °C
- Solubility:
- Soluble to 100 mM in Water
- Appearance:
- Off-white to tan crystalline solid
- Hazard Symbols:
T- Risk Codes:
- 25-36/37/38
- Safety Description:
- 26-28-36/37-45 Details
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Chemistry
Following is the structure of Cytisine (CAS NO.485-35-8):
Molecular Formula: C11H14N2O
Molecular Weight: 190.27
EINECS: 207-616-0
Molar Refractivity: 54.04 cm3
Molar Volume: 153.2 cm3
Density: 1.24 g/cm3
Flash Point: 203.6 °C
Index of Refraction: 1.623
Melting Point: 154-156 °C
Surface Tension: 50.8 dyne/cm
Enthalpy of Vaporization: 66.58 kJ/mol
Boiling Point: 413 °C at 760 mmHg
Vapour Pressure: 4.95E-07 mmHg at 25 °C
Appearance of Cytisine (CAS NO.485-35-8): Off-White to Tan Crystalline Solid
Product Categories of Cytisine (CAS NO.485-35-8): Heterocyclic Compounds; Neurochemicals; Nicotine Derivatives
Canonical SMILES: C1C2CNCC1C3=CC=CC(=O)N3C2
InChI: InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2
InChIKey: ANJTVLIZGCUXLD-UHFFFAOYSA-N
Uses
Toxic priniciple in seed of Laburnum anagyroides and other Leguminosae. A neuronal nicotinic acetylcholine agonist.
Toxicity Data With Reference
| 1. | scu-rat LDLo:20 mg/kg | 85IXA4 Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif Bovet, D., andF. Bovet-Nitti,New York, NY.: S. Karger,1948,589. | ||
| 2. | orl-mus LD50:101 mg/kg | BJPCBM British Journal of Pharmacology. 35 (1969),161. | ||
| 3. | ipr-mus LD50:9400 µg/kg | BJPCBM British Journal of Pharmacology. 35 (1969),161. | ||
| 4. | ivn-mus LD50:1730 µg/kg | BJPCBM British Journal of Pharmacology. 35 (1969),161. | ||
| 5. | inv-cat LD50:400 µg/kg | ITOBAO Izvestiya Akademii Nauk Tadzhikskoi SSR, Otdelenie Biologicheskikh Nauk.(2),(1978),104. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by ingestion, intravenous and intraperitoneal routes. A toxin found in some plants. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
T
Risk Statements: 25-36/37/38
R25 :Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-28-36/37-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HA4025000
HazardClass: 6.1(b)
PackingGroup: III
Specification
Cytisine , its cas register number 485-35-8. It also can be called (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one ; and 1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)- .