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Toxicity Data With Reference

1.   

ivn-man TDLo:12 µg/kg

    JAMAAP    JAMA, Journal of the American Medical Association. 241 (1979),164.
2.   

unr-man LDLo:29 mg/kg

    85DCAI    Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
3.   

ipr-rat LDLo:50 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 1 (1959),156.
4.   

ivn-mus LDLo:200 mg/kg

    AEXPBL    Archiv fuer Experimentelle Pathologie und Pharmakologie. 82 (1917),1.
5.   

orl-cat LD50:244 mg/kg

    JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 44 (1955),607.
6.   

ivn-cat LDLo:62 mg/kg

    JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 44 (1955),607.
7.   

ipr-pgn LD50:220 mg/kg

    JPPMAB    Journal of Pharmacy and Pharmacology. 14 (1962),96.
8.   

ivn-pgn LDLo:670 mg/kg

    JPPMAB    Journal of Pharmacy and Pharmacology. 14 (1962),96.

Safety Profile

A deadly human poison by intravenous route. An experimental poison by ingestion, intravenous, and intraperitoneal routes. 2.5 g or 30 cc of the tincture is a toxic dose. An overdose can be fatal. It has been implicated in aplastic anemia. It contains digitalin, digitalein, digitonin, and digitoxin (the most toxic component). See also individual components.

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