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Name |
DIPHENYLACETIC ACID |
EINECS | 204-185-0 |
CAS No. | 117-34-0 | Density | 1.174 g/cm3 |
PSA | 37.30000 | LogP | 2.90310 |
Solubility | Slightly soluble in water(0.13g/L). | Melting Point |
147-149 °C(lit.) |
Formula | C14H12O2 | Boiling Point | 285 °C at 760 mmHg |
Molecular Weight | 212.248 | Flash Point | 140.4 °C |
Transport Information | N/A | Appearance | white to creamy-white crystalline powder |
Safety | 24/25-36/37-26 | Risk Codes | 36/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
2,2-diphenylacetic acid;2,2-diphenylacetate;Acetic acid, diphenyl-;p-methoxyphenylaceticacid;Benzeneacetic acid, alpha-phenyl-;1,1-Diphenylacetic acid;Benzeneacetic acid, .alpha.-phenyl-;alpha-Toluic acid, alpha-phenyl-;Benzeneacetic acid,R-phenyl-; |
Article Data | 220 |
benzhydryl 3,3,3-triphenylpropyl ether
A
2,2-diphenylacetic acid
B
3,3,3-triphenylpropan-1-ol
Conditions | Yield |
---|---|
With naphthalene; lithium In tetrahydrofuran | A 100% B 83% |
α,α-bromodiphenylacetyl bromide
2,2-diphenylacetic acid
Conditions | Yield |
---|---|
With tetraethylammonium chloride; sodium thiosulfate In dichloromethane at 20℃; for 24h; electrochemical reaction; | 100% |
allyl 2,2-diphenylacetate
2,2-diphenylacetic acid
Conditions | Yield |
---|---|
With [2-(dicyclohexylphosphino)ethyl]trimethylammonium chloride; phenylsilane In tetrahydrofuran; water at 20℃; for 2h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With phosphonic Acid; methanesulfonic acid; sodium iodide In water at 95℃; for 24h; Inert atmosphere; | 99.3% |
With triethylsilane; perchloric acid In dichloromethane; water at 40℃; for 20h; | 94% |
With phosphorus; iodine weiteres Reagens: wss. Phosphorsaeure; |
Conditions | Yield |
---|---|
Stage #1: methyl 2,2-diphenylacetate With potassium hydroxide In methanesulfonic acid at 65℃; Stage #2: With hydrogenchloride In water pH=2; | 99% |
With sodium hydroxide In ethanol at 85℃; for 6h; | 85% |
With potassium hydroxide In methanol at 35℃; for 0.5h; | 83% |
With water; indium (III) iodide; silica gel for 1.5h; Hydrolysis; Irradiation; | 70% |
With sodium hydroxide In methanol; water for 3h; Reflux; |
2,2-diphenylacetic acid
Conditions | Yield |
---|---|
With iron(III) chloride In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Green chemistry; | 99% |
Conditions | Yield |
---|---|
Stage #1: Diphenylmethane With N,N,N,N,-tetramethylethylenediamine; sodium 2,2,6,6-tetramethylpiperidide In hexane at 20℃; for 1h; Inert atmosphere; Sealed tube; Stage #2: carbon dioxide In hexane at 20℃; for 0.0833333h; Inert atmosphere; Sealed tube; | 96% |
With n-butyllithium 1.) methylcyclohexane, THF, from 0 deg C to 25 deg C, 20 h, 2.) methylcyclohexane, THF, ether; Yield given. Multistep reaction; | |
With lithium diisopropylamide 1.) THF, cyclohexane, RT, 30 min; Yield given. Multistep reaction; | |
With i-Pr2NNa*TMEDA 1.) cyclohexane, THF, 21 deg C, 30 min, 2.) cyclohexene, THF; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With sodium hypochlorite; lithium hypochlorite In ethanol at 77℃; for 2h; | 95% |
Conditions | Yield |
---|---|
With sodium sulfate; ascorbic acid In chloroform-d1; water-d2; acetonitrile for 1h; UV-irradiation; | A 92.8% B n/a |
Conditions | Yield |
---|---|
With salcomine; tetrabutylammonium perchlorate In acetonitrile at 25℃; electrochemical reaction; | 92.6% |
With samarium; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; under 760.051 Torr; for 2h; Electrochemical reaction; Cooling with ice; | 66% |
(i) tBuCl, Li, Et2O, (ii) /BRN= 1900390/; Multistep reaction; |
1. | orl-rat LD50:5540 mg/kg | GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. 17 (1978),48. | ||
2. | orl-mus LD50:3200 mg/kg | GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. 17 (1978),48. | ||
3. | ipr-mus LD50:500 mg/kg | FRPSAX Farmaco, Edizione Scientifica. 13 (1958),286. | ||
4. | scu-mus LD50:400 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 116 (1958),154. |