Basic information
- Name:
1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl-
- CAS No.:
53-85-0
- Molecular Structure:
- Formula:
- C12H12 Cl2 N2 O4
- Synonyms:
- Benzimidazole,5,6-dichloro-1-D-ribofuranosyl- (6CI); Benzimidazole, 5,6-dichloro-1-b-D-ribofuranosyl- (7CI,8CI); 1-b-D-Ribofuranosyl-5,6-dichlorobenzimidazole;5,6-Dichloro-1-(b-D-ribofuranosyl)benzimidazole;DRB; NSC 401575
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Chemistry
Molecular Structure of DRB (CAS NO.53-85-0) :
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IUPAC Name:2-(5,6-Dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Product Categories: Bases & Related Reagents;Inhibitors;Nucleotides
CAS NO: 53-85-0
Molecular Formula: C12H12Cl2N2O4
Molecular Weight: 319.14
Mol File: 53-85-0.mol
Index of Refraction: 1.749
Surface Tension: 70.7 dyne/cm
Density: 1.84 g/cm3
Flash Point: 320.4 °C
Enthalpy of Vaporization: 94.75 kJ/mol
Boiling Point: 606.2 °C at 760 mmHg
Vapour Pressure: 1.51E-15 mmHg at 25 °C
Melting point: 222-224 °C
Storage temp: -20 °C
Uses
DRB (CAS NO.53-85-0) is used as an inhibitor of RNA synthesis (causes premature termination of transcription).
Toxicity Data With Reference
| 1. | oms-oin:oth 65 µmol/L | BBACAQ Biochimica et Biophysica Acta. 697 (1982),213. | ||
| 2. | oms-hmn:hla 40 µmol/L | PNASA6 Proceedings of the National Academy of Sciences of the United States of America. 79 (1982),2569. |
Safety Profile
WGK Germany: 3
RTECS of DRB (CAS NO.53-85-0): DD7310000
Specification
DRB (CAS NO.53-85-0), its Synonyms are 1H-Benzimidazole, 5,6-dichloro-1-.beta.-D-ribofuranosyl- ; 1H-Benzimidazole, 5,6-dichloro-1-beta-D-ribofuranosyl- ; 5,6-Dichloro-1-.beta.-D-ribofuranosylbenzimidazole ; Benzimidazole, 5,6-dichloro-1-.beta.-D-ribofuranosyl- ; 1H-Benzimidazole, 5,6-dichloro-1-beta-D-ribofuranosyl- (9CI) ; 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole ; 5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside ; 5,6-Dichlorobenzimidazole riboside .
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