Daptomycin (103060-53-3),Daptomycin (103060-53-3) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Daptomycin
CAS No.:
103060-53-3
Molecular Structure:
Formula:
C₇₂H₁₀₁ N₁₇ O₂₆
Molecular Weight:
1620.67
Synonyms:
Benzenebutanoic acid, N-(1-oxodecyl)-L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithyl-L-a-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a-glutamyl-a,2-diamino-g-oxo-, (13?;4)-lactone, (aS)-;Cidecin;Cubicin;Dapcin;Daptomicina;Daptomycine;Daptomycinum;Deptomycin;LY 146032;N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithyl-L-a-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a-glutamyl-(aS)-a,2-diamino-g-oxobenzenebutanoicacid (13?;
Density:
1.45 g/cm³
Boiling Point:
2078.2 °C at 760 mmHg
Flash Point:
1210.7 °C

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Chemistry

Molecular Formula: C₇₂H₁₀₁N₁₇O₂₆
Molecular Weight: 1619.7086 g/mol
Density: 1.45 g/cm³
Index of Refraction: 1.638
Flash Point: 1210.7 °C
Enthalpy of Vaporization: 366.93 kJ/mol
Boiling Point: 2078.2 °C at 760 mmHg
Structure of Daptomycin (CAS NO.103060-53-3):

Product Category of Daptomycin (CAS NO.103060-53-3): Antibacterial;Intermediates & Fine Chemicals;Pharmaceuticals

History

Daptomycin (CAS NO.103060-53-3) was originally discovered by researchers at Eli Lilly and Company in the 1980s, who designated the compound LY 146032. It showed promise in Phase I/II clinical trials for the treatment of infections caused by Gram-positive organisms. However, high dose therapy was found to be associated with adverse effects on skeletal muscle, including myalgia and the potential for myositis, and Lilly ceased development. The rights to LY 146032 were subsequently acquired by Cubist Pharmaceuticals in 1997. Food and Drug Administration (FDA) approval in September 2003. Daptomycin is marketed in the EU and several other countries by Novartis following its buying of Chiron Corporation. Outside of the US, Daptomycin is available in Canada and many European countries, with further launches expected in 2008.

Uses

Daptomycin (CAS NO.103060-53-3) is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Its distinct mechanism of action means that it may be useful in treating infections caused by multi-resistant bacteria.

Production

Daptomycin (CAS NO.103060-53-3) is a naturally-occurring compound found in the soil saprotroph Streptomyces roseosporus.

Specification

Daptomycin , its cas register number is 103060-53-3. It also can be called Cubicin ; and N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone .