Diazinon (333-41-5),Diazinon (333-41-5) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Diazinon
CAS No.:
333-41-5
Molecular Structure:
Formula:
C₁₂H₂₁N₂O₃PS
Molecular Weight:
304.38
Deleted CAS:
65863-03-8|30583-38-1|27936-40-9
Synonyms:
Dassitox;Topclip 40;Diazinon AG 500;diethoxy-(6-methyl-2-propan-2-yl-pyrimidin-4-yl)oxy-sulfanylidene-phosphorane;Sarolex;Diazol;Drawizon;O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate;Isopropylmethylpyrimidyl diethyl thiophosphate;o, o-Dietil-o- (2-isopropil-4-metil-pirimidin-il)-monotiofosato(ITALIA N);Ektoband;Kleen-Dok;O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate;Diazajet;Dimpylat;Phosphorothioic acid, O, O-diethyl O- (2-isopropyl-6-methyl-4-pyrimidinyl) ester;Topclip Blue Shield;O, O-Diethyl-O- (2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat( DUTCH);O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) thiophosphate;Basudin 10 G;Antigal;O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate;Diazitol;Phosphorothioic acid, O,O-diethyl {O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl]} ester;O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate;Phosphorothioic acid, O,O-diethyl O-[6-methyl-2- (1-methylethyl)-4-pyrimidinyl] ester;Galesan;Exodin;Cooper's Flystrike Powder;Dizictol;4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate;Bazudin;Delzinon;G-24480;Dimpylate;Knox-out;O, O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate;Diazinone;Nedcidol;Disonex;Garden Tox;KFM Blowfly Dressing;Spectracide;Phosphorothioate, O,O-diethyl O-6- (2-isopropyl-4-methylpyrimidyl);Flytrol;Bazanon;Nucidol;Topclip Blue;
EINECS:
206-373-8
Density:
1.168 g/cm³
Melting Point:
>120 °C (dec.)
Boiling Point:
353.9 °C at 760 mmHg
Flash Point:
167.9 °C
Solubility:
slightly soluble in water
Appearance:
light to dark brown liquid
Hazard Symbols:
Xn, N, F
Risk Codes:
22-50/53-36-20/21/22-11
Safety Description:
24/25-60-61-36-26-16 Details
Transport Information:
UN 2783/2810

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Chemistry

Product Name: Diazinon (CAS NO.333-41-5)

Molecular formula :C₁₂H₂₁N₂O₃PS
Molar mass :304.35 g/mol
Appearance :Colorless to dark brown liquid
Index of Refraction: 1.523
Molar Refractivity: 79.64 cm³
Molar Volume: 260.4 cm³
Surface Tension: 45.6 dyne/cm
Density: 1.168 g/cm³
Flash Point: 167.9 °C
Enthalpy of Vaporization: 57.53 kJ/mol
Boiling Point: 353.9 °C at 760 mmHg
Vapour Pressure: 7.07E-05 mmHg at 25°C
XLogP3-AA: 3.8
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Diazinon (CAS NO.333-41-5):
IUPAC Name: diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-λ5-phosphane
Canonical SMILES: CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C
InChI: InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
InChIKey: FHIVAFMUCKRCQO-UHFFFAOYSA-N
Classification Code: Acaricide; Agricultural Chemical; Cholinergic Agents; Cholinesterase inhibitors Enzyme Inhibitors; Human Data; Insecticide; Insecticides; Mutation data; Nematocide; Neurotransmitter Agents; Pesticides; Reproductive Effect; Skin / Eye Irritant; Tumor data

History

In 1952 , Diazinon is a thiophosphoric acid ester developed by Ciba-Geigy, a Swiss chemical company . It is a nonsystemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon was heavily used during the 1970s and early 1980s for general-purpose gardening use and indoor pest control. A bait form was used to control scavenger wasps in the western U.S.

Uses

Among cultivators of carnivorous plants, diazinon is known as the most effective systemic insecticide, capable of eradicating severe infestations of aphids, mealybugs and other sucking parasites while leaving the plant unharmed. For cultivators unable to obtain diazinon, Malathion and Acephate have been reported as less effective substitutes.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	2mg/kg (2mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
chicken	LD50	oral	8400ug/kg (8.4mg/kg)		"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
duck	LD50	oral	3500ug/kg (3.5mg/kg)		Down to Earth. Vol. 35, Pg. 25, 1979.
guinea pig	LC50	inhalation	5500mg/m³/4H (5500mg/m³)		Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974.
guinea pig	LD50	oral	250mg/kg (250mg/kg)		"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
human	TDLo	oral	214mg/kg (214mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Clinical Toxicology. Vol. 12, Pg. 435, 1978.
mammal (species unspecified)	LD50	unreported	76mg/kg (76mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 338, 1971.
mouse	LC50	inhalation	1600mg/m³/4H (1600mg/m³)		Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974.
mouse	LD50	intraperitoneal	33mg/kg (33mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960.
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00023,
mouse	LD50	oral	17mg/kg (17mg/kg)		Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 24, Pg. 268, 1983.
mouse	LD50	skin	2750mg/kg (2750mg/kg)		Journal of Toxicology and Environmental Health. Vol. 9, Pg. 491, 1982.
mouse	LD50	subcutaneous	58mg/kg (58mg/kg)		Osaka Igaku Zasshi. Vol. 71, Pg. 6099, 1959.
pig	LD50	oral	320mg/kg (320mg/kg)		Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
pig	LD50	skin	633mg/kg (633mg/kg)		Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
pigeon	LD50	oral	3160ug/kg (3.16mg/kg)		ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail	LD50	oral	4210ug/kg (4.21mg/kg)		ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rabbit	LD50	oral	143mg/kg (143mg/kg)		Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
rabbit	LD50	skin	3600mg/kg (3600mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A131, Pg. 1983,
rat	LC50	inhalation	3500mg/m3/4H (3500mg/m3)		Farm Chemicals Handbook. Vol. -, Pg. C101, 1991.
rat	LD50	intraperitoneal	65mg/kg (65mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 436, 1955.
rat	LD50	intratracheal	210mg/kg (210mg/kg)		JAT, Journal of Applied Toxicology. Vol. 19, Pg. 133, 1999.
rat	LD50	oral	66mg/kg (66mg/kg)		Down to Earth. Vol. 35, Pg. 25, 1979.
rat	LD50	skin	180mg/kg (180mg/kg)		Proceedings of the Annual Meeting of the New Jersey Mosquito Extermination Association. Vol. -, Pg. 155, 1957.
rat	LD50	unreported	250mg/kg (250mg/kg)		Rinsho Shinkeigaku. Clinical Neurology. Vol. 23, Pg. 101, 1983.

Safety Profile

Safety Information of Diazinon (CAS NO.333-41-5):
Hazard Codes: Xn Harmful ;N Dangerous
Risk Statements: R22;R50/53
R22:Harmful if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: S24/25;S60;S61
S24:Avoid contact with skin.
S25:Avoid contact with eyes.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Specification

Diazinon , its CAS NO. is 333-41-5, the synonyms are O,O-Diethyl O-2-isopropyl-4-methyl-6-pyrimidyl thiophosphate ; O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate .