Basic information
- Name:
Dichloromethane
- CAS No.:
75-09-2
- Molecular Structure:
- Formula:
- CH2Cl2
- Molecular Weight:
- 84.93 .
- Synonyms:
- Dichloromethane [UN1593] [Poison];methane, dichloro-;Methylene chloride (NF);Aerothene MM;
- EINECS:
- 200-838-9
- Density:
- 1.252 g/cm3
- Melting Point:
- -97 °C
- Boiling Point:
- 39.6 °C at 760 mmHg
- Flash Point:
- 39-40 °C
- Solubility:
- Water solubility: 20 g/L (20 °C)
- Appearance:
- colorless liquid
- Hazard Symbols:
Xn,
T,
F- Risk Codes:
- 40-39/23/24/25-23/24/25-11
- Safety Description:
- 23-24/25-36/37-45-16-7 Details
- Transport Information:
- UN 1593 6.1/PG 3
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*Required Fields
Chemistry
Molecular Structure:
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Empirical Formula: CH2Cl2
Molecular Weight: 84.9326
CAS Registry Number: 75-09-2
EINECS: 200-838-9
Water Solubility: 20 g/L (20 ºC)
Merck: 14,6063
BRN: 1730800
Melting Point: -97 °C
Molar Refractivity: 16.38 cm3
Molar Volume: 67.8 cm3
Surface Tension: 23.1 dyne/cm
Index of Refraction: 1.398
Surface Tension: 23.1 dyne/cm
Density: 1.252 g/cm3
Enthalpy of Vaporization: 28.06 kJ/mol
Boiling Point: 39.6 °C at 760 mmHg
Vapour Pressure: 448 mmHg at 25°C
Storage temp: Store at RT
Synonyms of Dichloromethane (CAS NO.75-09-2): Dichlorométhane ; Dichloromethane [UN1593] [Poison] ; methane, dichloro- ; aerothene mm ; Methylene chloride (NF)
Product Categories: refrigerants ; Organics ; alpha,omega-Bifunctional Alkanes ; alpha,omega- Dichloroalkanes ; Analytical Chemistry;Monofunctional & alpha,omega-Bifunctional Alkanes ; Solvents for HPLC & Spectrophotometry ; Solvents for Spectrophotometry;Anhydrous Solvents;Synthetic Organic Chemistry ; HPLC Solvents;Standard Solution of Volatile Organic Compounds for Water & Soil Analysis ; Standard Solutions (VOC)
Production
There are many manufacturing methods in Dichloromethane (CAS NO.75-09-2), such as the distillation of chlorine chlorinated, methane chloride and methanol chlorination can be mainly used. General manufacturing method is use photo-chlorination or thermal chlorination, heat chlorination reaction temperature to reach 400°C, difficult to manufacture, commonly used photo-chlorination. Reaction equation:
CH3Cl + Cl2 → CH2Cl2 + HCl.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LCLo | inhalation | 43400mg/m3/4. (43400mg/m3) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA | Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936. |
| dog | LCLo | inhalation | 14108ppm/7H (14108ppm) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. |
| dog | LD50 | intraperitoneal | 1274mg/kg (1274mg/kg) | Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967. | |
| dog | LDLo | intravenous | 200mg/kg (200mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| dog | LDLo | oral | 3gm/kg (3000mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| guinea pig | LCLo | inhalation | 5000ppm/2H (5000ppm) | Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. | |
| human | LDLo | oral | 357mg/kg (357mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969. |
| human | TCLo | inhalation | 500ppm/1Y-I (500ppm) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CHANGE IN RATE | Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968. |
| human | TCLo | inhalation | 500ppm/8H (500ppm) | BEHAVIORAL: EUPHORIA | Science. Vol. 176, Pg. 295, 1972. |
| man | TDLo | oral | 1429uL/kg (1.429mL/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: NORMOCYTIC ANEMIA | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994. |
| mouse | LC50 | inhalation | 14400ppm/7H (14400ppm) | National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. | |
| mouse | LD50 | intraperitoneal | 437mg/kg (437mg/kg) | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960. | |
| mouse | LD50 | oral | 873mg/kg (873mg/kg) | EHP, Environmental Health Perspectives. Vol. 106(Suppl, | |
| mouse | LD50 | subcutaneous | 6460mg/kg (6460mg/kg) | Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962. | |
| mouse | LD50 | unreported | 4770mg/kg (4770mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982. |
| rabbit | LCLo | inhalation | 10000ppm/7H (10000ppm) | Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944. | |
| rabbit | LD50 | unreported | 1225mg/kg (1225mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. | |
| rabbit | LDLo | oral | 1900mg/kg (1900mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955. | |
| rabbit | LDLo | subcutaneous | 2700mg/kg (2700mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| rat | LC50 | inhalation | 52gm/m3 (52000mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. | |
| rat | LD50 | intraperitoneal | 916mg/kg (916mg/kg) | Environmental Research. Vol. 40, Pg. 411, 1986. | |
| rat | LD50 | oral | 1600mg/kg (1600mg/kg) | BEHAVIORAL: ATAXIA | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970. |
| rat | LD50 | unreported | 5350mg/kg (5350mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. | |
| rat | LDLo | intratracheal | 350mg/kg (350mg/kg) | LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | National Technical Information Service. Vol. OTS0520615, |
Safety Profile
Hazard Codes of Dichloromethane (CAS NO.75-09-2): 
Xn,
T,
F
Risk Statements: 40-39-23/24/25-11
R40:Limited evidence of a carcinogenic effect.
R39:Danger of very serious irreversible effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R11:Highly flammable.
Safety Statements: 23-24/25-36/37-45-16-7
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
RIDADR: UN 1593 6.1/PG 3
WGK Germany: 2
RTECS: PA8050000
F: 3-10
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
Specification
Dichloromethane (CAS NO.75-09-2) is a colorless liquid with a sweet, penetrating-like ether. If exposed to high temperatures , it may emit toxic chloride fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover. It is somewhat soluble in water, subjected to slow hydrolysis which is accelerated by light. It has some kinds of uses. Solvent is the most important use of methylene chloride. Dichloromethane with the dissolving ability, low boiling point and relatively low toxicity, so it has be made as the highest frequency use in organic synthesis. It can be used as extraction solvent, mainly as the extraction of caffeine in coffee beans, besides it can be used as hops, spices oil-resin extraction solvents, pigment thinner, organic synthesis. As a solvent for resins and plastics industry is widely used in pharmaceutical, plastics and film industries.