Because the heat of decomposition of Grignard reagents with water is great and the ether in which they are dissolved is highly volatile and flammable, they must be handled with extreme care. Some, especially the solution of MeMgBr in ethyl ether, may ignite spontaneously on contact with water or even damp floors; nearly all will ignite on a wet rag or similar material. Since all Grignard reagents react rapidly with both water and oxygen, contact must be avoided. Ordinary materials of construction are satisfactory for use with Grignard reagents. |