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Traube Purine Synthesis

    Traube Purine Synthesis
    Detailed information:
    Preparation of an appropriate 4,5-diaminopyrimidine by introduction of the amino group into the 5 position of 4-amino-6-hydroxy- or 4,6-diaminopyrimidines by nitrosation and ammonium sulfide reduction, followed by ring closure with formic acid or chlorocarbonic ester.