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Diethyl carbonate (105-58-8)

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Chemistry

IUPAC Name:diethyl carbonate
Molecular Formula:C5H10O3
Molecular Weight:118.131100 g/mol
Appearance:characteristic odor colorless clear liquid
Melting Point:-43 °C
Boiling Point:126-128 °C(lit.)
Flash Point:88 °F
Solubility:alcohol, ether and other organic solvents
Water Solubility:Negligible
density:0.975 g/mL at 25 °C(lit.)
vapor density:4.1 (vs air)
vapor pressure:10 mm Hg ( 23.8 °C)
refractive index:n20/D 1.384(lit.)
Sensitive:Moisture
Merck:14,3780
BRN:956591
EINECS:212-786-4
Synonyms of Diethyl carbonate(105-58-8):
Diaethylcarbonat;Diatol;Diethyl ester of carbonic acid;Diethylester kyseliny uhlicite;diethylesterkyselinyuhlicite;Diethylkarbonat;Ethyl carbonate ((EtO)2CO)
Categories of Diethyl carbonate(105-58-8):
Pharmaceutical Intermediates;Organics;CARBONATES;Others;Protecting and Derivatizing Reagents;Protection and Derivatization;CarbonatesMaterials Science;Alternative Energy;Carbonyl Compounds;Electrolytes;Organic Building Blocks;ElectrolytesProtection and Derivatization;Materials Science

Uses
Diethyl carbonate(105-58-8) is mainly used as a solvent for cellulose ethers, nitro cellulose, natural and synthetic resin.
Diethyl carbonate(105-58-8) is also used for the synthesis of phenobarbital, pyrethrum esters.
Production
1.Anhydrous ethanol reacts with phosgene to product ethyl chloride.
2.ethyl chloride reacts with ethyl alcohol to synthesize diethyl carbonate(105-58-8).
3.After wash, distil, we could get pure product.
Toxicity Data With Reference

Toxicity Information of Diethyl carbonate(105-58-8):
1.rat LD50 subcutaneous 8500mg/kg (8500mg/kg)
Compilation of LD50 Values of New Drugs. 
2.rat LDLo oral 15gm/kg (15000mg/kg)
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 52, 1974.

Consensus Reports
Diethyl carbonate (105-58-8) Market Research Report 2009
Safety Profile

Safety Information of Diethyl carbonate(105-58-8):
Hazard Codes:T ,Xi
Risk Statements:23/24/25-36/37/38-10
23/24/25:Toxic by inhalation, in contact with skin and if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
10:Flammable
Safety Statements:26-36-45-16-23
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
16:Keep away from sources of ignition-No smoking
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
RIDADR:UN 2811 6.1/PG 2
WGK Germany:3
RTECS:YE1050000
F:21
HazardClass:3
PackingGroup:III

Specification

First Aid Measures of Diethyl carbonate(105-58-8):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Storage of Diethyl carbonate(105-58-8):
Keep away from sources of ignition. Store in a cool, dry place. Keep container closed when not in use. Flammables-area.