Basic information
- Name:
Diethyl chlorothiophosphate
- CAS No.:
2524-04-1
- Molecular Structure:
- Formula:
- C4H10ClO2PS
- Molecular Weight:
- 188.62
- Synonyms:
- Ethylphosphorochloridothioate ((EtO)2ClPS) (6CI);(Chlorodiethoxy)phosphine sulfide;Diethoxythiophosphoryl chloride;Diethyl phosphorochlorothioate;Diethylthiophosphoryl chloride;O,O-Diethyl thionophosphoric chloride;O,O-Diethyl thionophosphoryl chloride;O,O-Diethyl thiophosphorochloridate;
- EINECS:
- 219-755-4
- Density:
- 1.251 g/cm3
- Melting Point:
- - 75 °C
- Boiling Point:
- 187.5 °C at 760 mmHg
- Flash Point:
- 75.8 °C
- Solubility:
- immiscible with water
- Appearance:
- clear colorless to light yellow liquid
- Hazard Symbols:
T,
T+- Risk Codes:
- 23/24/25-34-26-21/22
- Safety Description:
- 23-26-36/37/39-45-28 Details
- Transport Information:
- UN 2751 8/PG 2
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Chemistry
Empirical Formula: C4H10ClO2PS
Molecular Weight: 188.6128 g/mol
EINECS: 219-755-4
Index of Refraction: 1.483
Density: 1.251 g/cm3
Flash Point: 75.8 °C
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 187.5 °C at 760 mmHg
Vapour Pressure: 0.866 mmHg at 25 °C
Structure of Diethyl chlorothiophosphate (CAS NO.2524-04-1):
IUPAC Name of Diethyl chlorothiophosphate (CAS NO.2524-04-1): Chloro-diethoxy-sulfanylidene-λ5-phosphane
Product Categories of Diethyl chlorothiophosphate (CAS NO.2524-04-1): Pharmaceutical Intermediates;Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents
Uses
Diethyl chlorothiophosphate (CAS NO.2524-04-1) can be used for the synthesis of organophosphorus pesticides: phoxim, parathion, chlorpyrifos, diazinon triazophos, and so on.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | oral | 810mg/kg (810mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BLOOD: HEMORRHAGE | Hygiene and Sanitation Vol. 33(10-12), Pg. 334, 1968. |
| mouse | LC50 | inhalation | 725mg/m3/2H (725mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 51, 1982. | |
| mouse | LD50 | oral | 800mg/kg (800mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 51, 1982. | |
| mouse | LD50 | unreported | 750mg/kg (750mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 56(5), Pg. 6, 1991. | |
| rabbit | LD50 | oral | 900mg/kg (900mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BLOOD: HEMORRHAGE | Hygiene and Sanitation Vol. 33(10-12), Pg. 334, 1968. |
| rabbit | LDLo | skin | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: OTHER CHANGE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | National Technical Information Service. Vol. OTS0536769, |
| rat | LC50 | inhalation | 20ppm/4H (20ppm) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1172, 1986. | |
| rat | LD50 | oral | 1340mg/kg (1340mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BLOOD: HEMORRHAGE | Hygiene and Sanitation Vol. 33(10-12), Pg. 334, 1968. |
Safety Profile
Hazard Codes: 
T,
T+
Risk Statements: 23/24/25-34-26-21/22
R21/22: Harmful in contact with skin and if swallowed.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R26: Very toxic by inhalation.
R34: Causes burns.
Safety Statements: 23-26-36/37/39-45
S23: Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Specification
Diethyl chlorothiophosphate ,its cas register number is 2524-04-1. It also can be called Phosphorochloridothioic acid O,O-diethyl ester ; O,O-Diethyl chlorothiophosphate ;and O,O-diethyl chlorothiophosphate . It is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols, and may react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salt