The Diltiazem HCl, with the CAS registry number 33286-22-5, is also known as (+)-cis-3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)one monohydrochloride. It belongs to the product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Calcium Channel; Ion Channels; Aromatics; Chiral Reagents; Sulfur & Selenium Compounds. Its EINECS registry number is 251-443-3. This chemical's molecular formula is C₂₂H₂₇ClN₂O₄S and molecular weight is 450.98. What's more, both its IUPAC name and systematic name are the same which is called [(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate hydrochloride. It is used as a calcium channel blocher with vasodilating activity and an antianginal, antihypertensive.

Physical properties about Diltiazem HCl are: (1)ACD/LogP: 3.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.76; (4)ACD/LogD (pH 7.4): 2.26; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 14.49; (7)ACD/KOC (pH 5.5): 3.03; (8)ACD/KOC (pH 7.4): 96.24; (9)#H bond acceptors: 6; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 84.38 Å²; (13)Flash Point: 313.3 °C; (14)Enthalpy of Vaporization: 88.6 kJ/mol; (15)Boiling Point: 594.4 °C at 760 mmHg; (16)Vapour Pressure: 4.27E-14 mmHg at 25 °C.

Preparation of Diltiazem HCl: this chemical can be prepared by 2-Acetoxy-propene with (2S,3S)-5-(2-Dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride. This reaction needs reagent methanesulfonic acid, solvent CHCl₃ and other condition of heating for 45 min. The yield is 88.8 %.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. If swallowed, it's harmful to health. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: Cl.O=C2N(c3c(S[C@@H](c1ccc(OC)cc1)[C@H]2OC(=O)C)cccc3)CCN(C)C
(2) InChI: InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
(3) InChIKey: HDRXZJPWHTXQRI-BHDTVMLSSA-N

The toxicity data is as follows: