Basic information
- Name:
Diosmin
- CAS No.:
520-27-4
- Molecular Structure:
- Formula:
- C28H32O15
- Molecular Weight:
- 608.54 g/mol
- Synonyms:
- 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.- D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-;5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxymethyl]oxan-2-yl]oxy-chromen-4-one;4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy- R-L-mannopyranosyl)-a-D-glucopyranosyl]- oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-;Diosmetin 7-O-rutinoside;4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-;Diosmine [INN-French];Diosminum [INN-Latin];Diosmine;Venosmine;Diosmin Inn;
- EINECS:
- 208-289-7
- Density:
- 1.68 g/cm3
- Melting Point:
- 277-278 °C
- Boiling Point:
- 926.8 °C at 760 mmHg
- Flash Point:
- 305.2 °C
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-36-36/37 Details
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Chemistry
Molecular Formula: C28H32O15
Molecular Weight: 608.54 g/mol
EINECS: 208-289-7
Melting point: 277-278 °C
Storage temp.: 2-8 °C
Merck: 13,3327
Density: 1.68 g/cm3
Flash Point: 305.2 °C
Index of Refraction: 1.711
Surface Tension: 101.2 dyne/cm
Enthalpy of Vaporization: 141.22 kJ/mol
Boiling Point: 926.8 °C at 760 mmHg
Synonyms of Diosmin (CAS NO.520-27-4): Diosmetin-7-o-rutinoside ; Diosmetin-7-rutinoside ; Diosmin ; Barosmin ; 3',5,7-Trihydroxy-4'-methoxyflavone 7-rutinoside ; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside ; Diosmine ep4
Product Categories: Tetra-substituted Flavones;plant extract;Active pharmaceutical ingredients;Aromatics;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals
Molecular Structure of Diosmin (CAS NO.520-27-4):
Uses
Diosmin (CAS NO.520-27-4) is a semisynthetic phlebotropic drug which is a member of the flavonoid family. It is an oral phlebotropic drug used in the treatment of venous disease, chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. Diosmin (CAS NO.520-27-4) is also used with hesperidin to control internal symptoms of hemorrhoids (piles).
Consensus Reports
Diosmin (CAS NO.520-27-4) is reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes: 
Xi
WGK Germany: 3
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37:Wear suitable protective clothing and gloves.
Specification
Mechanisms of Diosmin (CAS NO.520-27-4):
1、Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
2、Diosmin prolongs the vasoconstrictor effect of noradrenaline on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
3、Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure
4、At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.