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Name |
Disodium 2-oxoglutarate dihydrate |
EINECS | 206-167-8 |
CAS No. | 305-72-6 | Density | 1.499g/cm3 |
PSA | 115.79000 | LogP | -3.29310 |
Solubility | soluble | Melting Point |
N/A |
Formula | C5H4Na2O5 | Boiling Point | 345.6 °C at 760 mmHg |
Molecular Weight | 190.063 | Flash Point | 177 °C |
Transport Information | N/A | Appearance | White powder. |
Safety | 22-24/25-45-36/37/39-26 | Risk Codes | 23/24/25-36/37/38 |
Molecular Structure | Hazard Symbols | T | |
Synonyms |
Glutaricacid, 2-oxo-, disodium salt (8CI);Pentanedioic acid, 2-oxo-, disodium salt(9CI);2-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Disodium2-oxopentanedioate;Disodium a-ketoglutarate;a-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Pentanedioic acid, 2-oxo-, disodium salt;α-Ketoglutaric acid disodium salt; |
Article Data | 2 |
2-oxoglutaric acid 1-ethyl ester
α-ketoglutaric acid disodium salt
Conditions | Yield |
---|---|
With [D]-sodium hydroxide; water-d2 for 0.00416667h; pH=11; | >= 95 %Spectr. |
Conditions | Yield |
---|---|
With sodium hydroxide In water at 25 - 35℃; Reagent/catalyst; Large scale; |
α-ketoglutaric acid disodium salt
Conditions | Yield |
---|---|
With water-d2 at 80℃; for 3h; Substitution; | 100% |
α-ketoglutaric acid disodium salt
calcium alpha-ketaglutarate
Conditions | Yield |
---|---|
With calcium chloride In water at 65 - 70℃; Large scale; | 77% |
Conditions | Yield |
---|---|
In dichloromethane; water at 20℃; | 75% |
In dichloromethane; water |
Conditions | Yield |
---|---|
In water at 80 - 85℃; Large scale; | 73% |
1-chloro-4-nitroso-benzene
α-ketoglutaric acid disodium salt
A
4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid
B
4-amino-phenol
C
2-amino-5-chlorophenol
D
N-(4-chloro-2-hydroxyphenyl)succinamic acid
Conditions | Yield |
---|---|
With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given; | A n/a B n/a C n/a D 2 mg |
1-chloro-4-nitroso-benzene
α-ketoglutaric acid disodium salt
A
4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid
B
2-amino-5-chlorophenol
C
N-(4-chlorophenyl)succinohydroxamic acid
D
N-(4-chloro-2-hydroxyphenyl)succinamic acid
Conditions | Yield |
---|---|
With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given; | A n/a B n/a C 1.5 mg D 2 mg |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium tetrahydroborate for 0.0833333h; Reduction; |
α-ketoglutaric acid disodium salt
Conditions | Yield |
---|---|
With isocitrate dehydrogenase; water-d2; NADPH at 37℃; for 2h; Substitution; |
Name:α-ketoglutaric acid,disodium salt(305-72-6)
Molecular Formula:C5H4O5.2Na
Molecular Weight: 190.06g/mol
EINECS: 206-167-8
Chemical Properties: white powder
Density: 1.499g/cm3
Boiling Point: 345.6°C at 760 mmHg
Flash Point: 177 °C
Solubility: soluble in water
Freely Rotating Bonds: 4
Polarizability: 10-24cm3
Enthalpy of Vaporization: 64.8 kJ/mol
Vapour Pressure: 1.08E-05 mmHg at 25°C
The chemical synonyms of α-ketoglutaric acid,disodium salt(305-72-6) are 2-oxo-pentanedioicacidisodiumsalt;DISODIUM 2-KETOGLUTARATE;DISODIUM 2-OXOGLUTARATE;ALPHA-KETOGLUTARIC ACID, SESQUISODIUM SALT;ALPHA-KETOGLUTARATE DISODIUM;ALPHA-KETOGLUTARIC ACID DISODIUM SALT;2-KETOGLUTARIC ACID DISODIUM SALT;2-KETOGLUTARIC ACID SODIUM SALT .The molecular structure of α-ketoglutaric acid,disodium salt(305-72-6) is.
α-ketoglutaric acid,disodium salt(305-72-6) is used as pharmaceutical intermediate.
1. | orl-rat LD50:7.1 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. | ||
2. | orl-rat TDLo:2 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. | ||
3. | orl-rat TDLo:4 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. |
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes: T
T: Toxic
Risk Statements: 23/24/25-36/37/38
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-45-36/37/39-26
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection