ETHAMBUTOL DIHYDROCHLORIDE (1070-11-7),ETHAMBUTOL DIHYDROCHLORIDE (1070-11-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Ethambutol dihydrochloride
CAS No.:
1070-11-7
Molecular Structure:
Formula:
C₁₀H₂₄N₂O₂^.2(HCl)
Molecular Weight:
240.82
Synonyms:
(+)-2,2-(Ethylenediimino)-di-1-butanol dihydrochloride;Prestwick_208;(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (R-(R*,R*))- (9CI);Ethambutol hydrochloride;CL 40881;(S-(R*,R*))-2,2-(Ethylenediimino)dibutan-1-ol dihydrochloride;1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-,dihydrochloride,(2S,2'S)-;Ethambutol hydrochloride (JP14/USP);Myambutol;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (S-(R*,R*))-;Ethambutol hydrochloride [USAN:JAN];(2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;Myambutol (TN);Ethambutol HCl;
EINECS:
213-970-7
Melting Point:
198-200 °C
Boiling Point:
345.3 °C at 760 mmHg
Flash Point:
113.7 °C
Appearance:
white powder
Hazard Symbols:
T,Xi
Risk Codes:
61-36/37/38
Safety Description:
53-22-36/37/39-45-36/37-26 Details

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Chemistry

IUPAC Name: (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
dihydrochloride
The MF of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7): C₁₀H₂₄N₂O₂·2(HCl)
The MW of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7): 277.23
EINECS: 213-970-7
Density: 0.987 g/cm³
Flash Point: 113.7 °C
Boiling Point: 345.3 °C at 760 mmHg
Index of Refraction: 1.477
Synonyms: ETHAMBUTOL HCL; Ethambutol Hydrochloride; 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; [S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride
The Structure of ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7):

Uses

ETHAMBUTOL DIHYDROCHLORIDE(1070-11-7) is used as antibacterial.

Toxicity Data With Reference

1.	mnt-mus-orl 50 mg/kg	IRLCDZ IRCS Medical Science: Library Compendium. 10 (1982),135.
2.	spm-mus-orl 12,500 µg/kg	IRLCDZ IRCS Medical Science: Library Compendium. 10 (1982),135.
3.	orl-man TDLo:45 mg/kg/3D-I:EYE	BJDCAT British Journal of Diseases of the Chest. 80 (1986),288.
4.	orl-man TDLo:46 mg/kg/3D-I:EYE	PGMJAO Postgraduate Medical Journal. 61 (1985),811.
5.	unr-wmn TDLo:720 mg/kg/48D:EYE	ANOPB5 Annals of Ophthalmology. 2 (1970),578.
6.	orl-rat LD50:6800 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 2 (1968),70.
7.	ipr-rat LD50:1200 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 2 (1968),70.
8.	ivn-rat LD50:300 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 2 (1968),70.
9.	orl-mus LD50:8900 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 2 (1968),70.
10.	scu-mus LD50:1800 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 2 (1968),70.
11.	<p class="cardite

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects: constriction of the pupil, visual field changes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x and HCl. See also AMINES.
Hazard Codes:

T: Toxic;
Risk Statements: R61: May cause harm to the unborn child
Safety Statements:
S53: Avoid exposure - obtain special instruction before use
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)