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Name |
Enoxolone |
EINECS | 207-444-6 |
CAS No. | 471-53-4 | Density | 1.14 g/cm3 |
PSA | 74.60000 | LogP | 6.41260 |
Solubility | Insoluble in water, but soluble in ethanol, chloroform, pyridine, acetic acid | Melting Point |
292-295 °C(lit.) |
Formula | C30H46O4 | Boiling Point | 588.3 °C at 760 mmHg |
Molecular Weight | 470.693 | Flash Point | 323.7 °C |
Transport Information | N/A | Appearance | white or greyish-white crystalline powder |
Safety | 22-24/25 | Risk Codes | 22-36 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Uralenic acid;(2S,4aR,6aS,6aS,6bR,8aS,10R,12aS,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate;Biosone;Hidermart;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-;Glycyrrhetic acid;3-Glycyrrhetinic acid;Glycyrrhetinate;10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid;β-Glycyrrhetinic Acid;Hidermart (TN);Glycyrrhetin;r-Glycyrrhetinic acid;Glycyrrhetinic acid;Glycyrrhetinic acid (JAN);(3β)-3-Hydroxy-11-oxoolean-12-en-30-oic acid; |
Article Data | 47 |
Conditions | Yield |
---|---|
With methanol; thionyl chloride at 0 - 20℃; for 9h; Reagent/catalyst; Inert atmosphere; | 90% |
With hydrogenchloride; water In methanol at 90℃; for 20h; | |
With hydrogenchloride In water at 100℃; for 20h; | |
With sulfuric acid In methanol Reflux; | 250 mg |
With methanol; sulfuric acid at 90℃; for 24h; |
enoxolone
Conditions | Yield |
---|---|
With hydrogenchloride In water | 85% |
Multi-step reaction with 2 steps 1: 18.4 percent / CHCl3; dimethylformamide / 72 h / Ambient temperature 2: 68.3 percent / 20percent H2SO4 / dioxane / 4 h View Scheme | |
With hydrogenchloride In ethanol; water at 30 - 35℃; for 48h; | 0.53% |
enoxolone
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetic acid at 100℃; for 1h; | 72% |
With hydrogenchloride; water In chloroform for 6h; Reflux; | 13 mg |
B
enoxolone
C
11-deoxyglycyrrhetinic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water at 100℃; for 8h; Hydrolysis; | A n/a B 69.9% C 1.1% |
6',6''-dibenzyl-18β-glycyrrhizin
enoxolone
Conditions | Yield |
---|---|
With sulfuric acid In 1,4-dioxane for 4h; | 68.3% |
enoxolone
Conditions | Yield |
---|---|
With sulfuric acid In water at 100℃; for 8h; Hydrolysis; | 68.3% |
Ammonium glycyrrhizate
enoxolone
Conditions | Yield |
---|---|
at 40℃; for 3h; 15percent aq. solution of β-glucuronidase, acetate buffer 4.6; | 48% |
With β-glucuronidase In water at 40℃; for 3h; Rate constant; Kinetics; Product distribution; acetate buffer 4.6; other temp., other pH, other time; | 48.08% |
B
enoxolone
Conditions | Yield |
---|---|
With β-glucuronidase In acetate buffer at 37℃; for 144h; pH=5.2; Hydrolysis; Enzymatic reaction; | A n/a B 45.9% |
11-deoxyglycyrrhetinic acid
B
enoxolone
Conditions | Yield |
---|---|
Stage #1: 11-deoxyglycyrrhetinic acid With ozone In methanol; dichloromethane at -60℃; Stage #2: With acetic acid; zinc In methanol; dichloromethane at 0℃; for 1h; Further stages.; | A 42% B n/a |
enoxolone
Conditions | Yield |
---|---|
With potassium hydroxide |
The Enoxolone, with the CAS registry number 471-53-4, is also known as 18-beta-Glycyrrhetinic acid. It belongs to the product categories of Pentacyclic Triterpenes; Tri-Terpenoids; Miscellaneous; Biochemistry; Terpenes; Terpenes (Others); Natural Plant Extract; Cosmetic Ingredients & Chemicals; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 207-444-6. This chemical's molecular formula is C30H46O4 and molecular weight is 470.68. What's more, its systematic name is (3β)-3-hydroxy-11-oxoolean-12-en-30-oic acid. Its classification code is Anti-Inflammatory Agents. It can be used as edible flavoring and sauces. It should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides. It is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties.
Physical properties of Enoxolone are: (1)ACD/LogP: 6.57; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.73; (4)ACD/LogD (pH 7.4): 3.93; (5)ACD/BCF (pH 5.5): 8289; (6)ACD/BCF (pH 7.4): 131.57; (7)ACD/KOC (pH 5.5): 12748.06; (8)ACD/KOC (pH 7.4): 202.35; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 52.6 Å2; (13)Index of Refraction: 1.562; (14)Molar Refractivity: 133.69 cm3; (15)Molar Volume: 411.6 cm3; (16)Polarizability: 52.99×10-24cm3; (17)Surface Tension: 47.7 dyne/cm; (18)Density: 1.14 g/cm3; (19)Flash Point: 323.7 °C; (20)Enthalpy of Vaporization: 100.81 kJ/mol; (21)Boiling Point: 588.3 °C at 760 mmHg; (22)Vapour Pressure: 2.71E-16 mmHg at 25°C.
Preparation: this chemical can be prepared by b-glycyrrhizic acid monopotassium salt at the temperature of 100 °C. This reaction will need reagent H2SO4 and solvent H2O with the reaction time of 8 hours. The yield is about 68.3%.
Uses of Enoxolone: it can be used to produce 3,11-dioxo-olean-12-en-30-oic acid at the temperature of 0 °C. It will need reagents CrO3, H2SO4 and solvent acetone with the reaction time of 1 hour. The yield is about 98%.
When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and is irritating to eyes. You should not breathe dust. When using it, you must avoid contact with eyes.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)[C@]5(C)C[C@H]4/C3=C/C(=O)[C@H]1[C@](CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C)(C)[C@]3(C)CC[C@@]4(C)CC5
(2)Std. InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,
(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
(3)Std. InChIKey: MPDGHEJMBKOTSU-YKLVYJNSSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 308mg/kg (308mg/kg) | Drugs in Japan Vol. -, Pg. 319, 1990. | |
mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02067, | |
mouse | LD50 | subcutaneous | 518mg/kg (518mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 5, Pg. 98, 1963. |