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Cas Database |
| Name |
Epirizole |
EINECS | 242-507-1 |
| CAS No. | 18694-40-1 | Density | 1.25g/cm3 |
| PSA | 62.06000 | LogP | 1.29630 |
| Solubility | N/A | Melting Point |
90-92° |
| Formula | C11H14 N4 O2 | Boiling Point | 444°Cat760mmHg |
| Molecular Weight | 234.258 | Flash Point | 222.3°C |
| Transport Information | N/A | Appearance | Yellow power |
| Safety | Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | R20/21/22;R36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
Pyrimidine,4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl- (8CI); 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;1-(4-Methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine;2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine;DA 398; Epirizole; Mebron; Mepirizole |
Article Data | 12 |
Epirizole Chemical Properties
Product Name: Mepirizol (CAS NO.18694-40-1)
Molecular Formula: C11H14N4O2
Molecular Weight: 234.25g/mol
Mol File: 18694-40-1.mol
Einecs: 242-507-1
Appearance: White or cream-colored crystals
Boiling point: 444 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 222.3 °C
Density: 1.25 g/cm3
Surface Tension: 40.1 dyne/cm
Enthalpy of Vaporization: 70.17 kJ/mol
Vapour Pressure: 4.43E-08 mmHg at 25°C
XLogP3: 1.3
H-Bond Donor: 0
H-Bond Acceptor: 5
Epirizole Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978. |
| mouse | LD50 | intravenous | 550mg/kg (550mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
| mouse | LD50 | oral | 740mg/kg (740mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978. |
| mouse | LD50 | subcutaneous | 550mg/kg (550mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977. | |
| rat | LD50 | intraperitoneal | 214mg/kg (214mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
| rat | LD50 | intravenous | 214mg/kg (214mg/kg) | "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 87, 1975. | |
| rat | LD50 | oral | 445mg/kg (445mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
| rat | LD50 | subcutaneous | 208mg/kg (208mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977. |
Epirizole Safety Profile
Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Mepirizol (CAS NO.18694-40-1):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 20/21/22-36/37/38
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
Epirizole Specification
Mepirizol ,its CAS NO. is 18694-40-1,the synonyms is 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole ; 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine ; 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-pyrimidin ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin ; Da-398 ; Mebron .
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