The Journal of Clinical Sleep Medicine published a paper which had carried out a systematic review of the medical literature concerning insomnia medications including Eszopiclone. The review found that almost all trials of sleep disorders and drugs are sponsored by the pharmaceutical industry. It was found that the odds ratio for finding results favorable to industry in industry-sponsored trials was 3.6 times higher than non-industry-sponsored studies. The paper found that there is little research into hypnotics that is independent from the drug manufacturers. The author was concerned that there is no discussion of adverse effects of sedative hypnotics discussed in the medical literature such as significant increased levels of infection, cancers and increased mortality in Eszopiclone and other sedative hypnotic drugs and an overemphasis on the positive effects. The author concluded by stating that "major hypnotic trials are needed to more carefully study potential adverse effects of hypnotics such as daytime impairment, infection, cancer, and death and the resultant balance of benefits and risks."[21]

The Ethofumesate, with the CAS registry number 26225-79-6, has the systematic name of 2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate. And the molecular formula of this chemical is C₁₃H₁₈O₅S. In addition. it belongs to the following product categories: Benzofuranyl alkylsulfonate Alphabetic; E; EQ - EZ; Herbicides; Pesticides & Metabolites; Benzofuranyl alkylsulfonate Pesticides & Metabolites; Alpha sort; E-GAlphabetic. What's more, it should be stored at 0-6°C.

The physical properties of Ethofumesate are as following: (1)ACD/LogP: 2.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 19.38; (6)ACD/BCF (pH 7.4): 19.38; (7)ACD/KOC (pH 5.5): 290.49; (8)ACD/KOC (pH 7.4): 290.49; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 70.21 Å²; (13)Index of Refraction: 1.545; (14)Molar Refractivity: 71.13 cm³; (15)Molar Volume: 224.6 cm³; (16)Polarizability: 28.2×10^-24cm³; (17)Surface Tension: 46.2 dyne/cm; (18)Density: 1.27 g/cm³; (19)Flash Point: 201.2 °C; (20)Enthalpy of Vaporization: 63.55 kJ/mol; (21)Boiling Point: 409.1 °C at 760 mmHg; (22)Vapour Pressure: 1.58E-06 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is toxic to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. Therefore, you had better take the following instructions: Avoid release to the environment. Refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(Oc2cc1c(OC(OCC)C1(C)C)cc2)C
(2)InChI: InChI=1/C13H18O5S/c1-5-16-12-13(2,3)10-8-9(18-19(4,14)15)6-7-11(10)17-12/h6-8,12H,5H2,1-4H3
(3)InChIKey: IRCMYGHHKLLGHV-UHFFFAOYAI

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	> 1600mg/kg (1600mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A184, Pg. 1984,
quail	LD50	unreported	6gm/kg (6000mg/kg)		Defense des Vegetaux. Vol. 30, Pg. 23, 1976.
rabbit	LD50	oral	> 1gm/kg (1000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A184, Pg. 1984,
rat	LD50	oral	1130mg/kg (1130mg/kg)		National Technical Information Service. Vol. PB85-143766,
rat	LD50	skin	1440mg/kg (1440mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A184, Pg. 1984,