Fluconazole

Molecular Structure:

Molecular Formula: C₁₃H₁₂F₂N₆O
Molecular Weight: 306.2708
IUPAC Name: 2-(2,4-Difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
Synonyms of Fluconazole (CAS NO.86386-73-4): 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol ; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol ; Baten ; Biocanol ; Biozolene ; CCRIS 7211 ; Canzol ; Cryptal ; DRG-0005 ; Diflucan ; Diflucan in dextrose 5% in plastic container ; Diflucan in sodium chloride 0.9% ; Diflucan in sodium chloride 0.9% in plastic container ; Dimycon ; Elazor ; Flucazol ; Fluconazol ; Fluconazol [Spanish] ; Fluconazole in dextrose 5% in plastic container ; Fluconazole in sodium chloride 0.9% ; Fluconazole in sodium chloride 0.9% in plastic container ; HSDB 7420 ; Mutum ; Oxifugol ; Pritenzol ; Syscan ; Triflucan ; UK 49858 ; UNII-8VZV102JFY ; Zemyc ; Zonal ; alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol ; 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-
CAS NO: 86386-73-4
Classification Code: Anti-Infective Agents ; Antifungal ; Antifungal agents ; Drug / Therapeutic Agent ; Human Data
Melting point: 138-140°C 
Index of Refraction: 1.663
Molar Refractivity: 76.06 cm³
Molar Volume: 205.2 cm³
Surface Tension: 55.4 dyne/cm
Density: 1.49 g/cm³
Flash Point: 304.4 °C
Enthalpy of Vaporization: 91.24 kJ/mol
Boiling Point: 579.8 °C at 760 mmHg
Vapour Pressure: 2.78E-14 mmHg at 25°C

 Fluconazole (CAS NO.86386-73-4) is used in the treatment and prophylaxis of fungal infections where other antifungals are not worked or not tolerated (e.g. due to adverse effects), including:
1)Candidiasis caused by susceptible strains of Candida
2)Tinea corporis, tinea cruris or tinea pedis
3)Onychomycosis
4)Cryptococcal meningitis
 Fluconazole can be used first-line for the following indications:
Histoplasmosis
Coccidioidomycosis
Cryptococcosis
Prophylaxis of candidiasis in immunocompromised people

"The efficacy of Fluconazole (CAS NO.86386-73-4) in the treatment of onchomycosis (fungal infection of the nails) has not been demonstrated." I was treated with Apo-Fluconazole for onychomycosis, and it would seem that it works fine. Although I don't have any medical experience, I was wondering if someone would comment on this statement for me. Schnarr 01:48, 20 April 2006 (UTC)
I had phimosis and my doctor prscribed it as one of the medicines... I am wondering if dealing with a possible fungal infection can stop the preputial ring from forming... please give me some feedback if you have had this problem and how it was solved.. Brian (brianmatambo@gmail.com)

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37/39-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S24/25: Avoid contact with skin and eyes.
RTECS: XZ4810000
 Fluconazole (CAS NO.86386-73-4) is contraindicated in patients with:
Pregnancy
Known hypersensitivity to fluconazole or other azole antifungals
Concomitant use of cisapride, due to risk of serious cardiac arrhythmias (relative contraindication).