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Cas Database

Name	Flavone	EINECS	208-383-8
CAS No.	525-82-6	Density	1.24 g/cm³
PSA	30.21000	LogP	3.46000
Solubility	Soluble in acetone (25 mg/ml), methanol, alcohol, and chloroform. Insoluble in water.	Melting Point	94-97 °C(lit.)
Formula	C₁₅H₁₀O₂	Boiling Point	367.013 °C at 760 mmHg
Molecular Weight	222.243	Flash Point	171.058 °C
Transport Information	N/A	Appearance	white crystalline powder
Safety	26-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	2-Phenyl-4H-1-benzopyran-4-one;2-Phenyl-4H-chromen-4-one;2-Phenyl-g-benzopyrone;Chromocor;NSC 19028;	Article Data	312

Flavone Synthetic route

: 1469-94-9
1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
copper dichloride In ethanol at 80℃; for 0.0833333h; microwave irradiation;	98%
With potassium hydrogensulfate at 120℃; for 2h; Temperature; Green chemistry;	98%
With gallium(III) triflate In nitromethane at 80℃; for 2h;	97%

: 533-58-4
2-Iodophenol

: 201230-82-2
carbon monoxide

: 536-74-3
phenylacetylene

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With C22H28Br2N4Pd; diethylamine In N,N-dimethyl-formamide at 80℃; under 3000.3 Torr; for 24h; Autoclave;	98%
With diethylamine In N,N-dimethyl-formamide at 100℃; under 10343.2 Torr; for 24h; Sonogashira Cross-Coupling; Autoclave;	96%
With (trihexyl)(tetradecyl)phosphonium bromide; triethylamine; palladium dichloride at 110℃; under 760.051 Torr; for 24h; Autoclave;	95%

: 100-52-7
benzaldehyde

: 582-24-1
1-phenyl-2-hydroxyethanone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium molybdate In hexan-1-ol at 70℃; for 3h;	98%

: 487-26-3
Flavanone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With pyrrolidone hydrotribromide In dimethyl sulfoxide at 80℃; for 2h;	97%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%

: 888-12-0
(E)-2'-hydroxy-chalcone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With indium(III) bromide; silica gel at 130 - 140℃; for 0.75h;	96%
With iodine In dimethyl sulfoxide for 1h; Reflux;	85%
With iodine In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 150℃; for 4h; Product distribution; Further Variations:; Solvents; Temperatures; reaction times;	83%

: 16619-68-4
1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With dmap In N,N-dimethyl-formamide at 0 - 30℃; for 1.5h; Morita-Baylis-Hillman reaction; Inert atmosphere; regioselective reaction;	96%
With thallium(III) toluene-p-sulfonate In methanol at 65℃; for 6h; Reagent/catalyst; Solvent; Time; regioselective reaction;	91%
With lithium tert-butoxide In N,N-dimethyl-formamide at 20℃; for 0.166667h; Reagent/catalyst; Time; Temperature;	90%

: 81995-11-1
1-(2-hydroxyphenyl)-2-(triphenylphosphoranylidene)ethanone

: 98-88-4
benzoyl chloride

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With pyridine In toluene for 5h; Heating;	96%

: 1214-47-7
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With Iodine monochloride; dimethyl sulfoxide at 50℃; for 0.5h; Temperature; Reagent/catalyst; Sonication; Green chemistry;	96%
With cerium (IV) sulfate tetrahydrate; silica gel In neat (no solvent) at 100℃; for 4h; Concentration; Time; Green chemistry;	94%
With copper(l) iodide; oxygen at 50℃; under 760.051 Torr; for 48h; oxa-Michael-oxidation; Ionic liquid;	92%

: 223511-19-1
1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With diethylamine In ethanol for 24h; Heating;	96%

: 16619-51-5
2'-allyloxychalcone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 120℃; for 0.5h; regioselective reaction;	96%
Multi-step reaction with 2 steps 1: acetic acid / 24 h / 20 °C 2: iodine / dimethyl sulfoxide / 0.5 h / 130 °C View Scheme

Flavone Chemical Properties

Synonyms :2-Phenyl-4H-1-benzopyran-4-one; 2-Phenylchromone
MF: C₁₅H₁₀O₂
MW: 222.24
EINECS: 208-383-8
2-PHENYLCHROMONE(525-82-6),its melting point is about 94-97 °C(lit.),boiling point is 185 °C / 1mmHg .
Following is the molecular structure of 2-PHENYLCHROMONE(525-82-6):

Flavone Toxicity Data With Reference

1.	dni-hmn:fbr 100 mg/L	BCPCA6 Biochemical Pharmacology. 33 (1984),3823.
2.	orl-mus LD50:2500 mg/kg	JHTCAO Journal of Heterocyclic Chemistry. 21 (1984),193.
3.	ipr-mus LD50:380 mg/kg	FRPSAX Farmaco, Edizione Scientifica. 13 (1958),561.
4.	scu-mus LD >400 mg/kg	ANTCAO Antibiotics and Chemotherapy. 3 (1953),603.

RTECS : DJ3100630

Flavone Consensus Reports

Reported in EPA TSCA Inventory.

Flavone Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

Other safty informations about 2-PHENYLCHROMONE(525-82-6):
Hazard Codes: Xi (Irritant)
Risk Statements
R 36/37/38 (Irritating to eyes, respiratory system and skin )
Safety Statements :
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36 :Wear suitable protective clothing
WGK Germany : 2

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