EPA Genetic Toxicology Program.

1. Introduction of Fluocinolone acetonide

The Fluocinolone acetonide is a kind of crystalline solid, and it belongs to the following product categories which include Organics; Alkaloids; Biochemistry; Quinoline Alkaloids; Intermediates & Fine Chemicals; Pharmaceuticals; Steroids. What's more, it is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. And it is a synthetic hydrocortisone derivative.

2. Properties of Fluocinolone acetonide

The physical properties of Fluocinolone acetonide are as followings: (1)ACD/LogP: 2.24; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.24; (4)ACD/LogD (pH 7.4): 2.24; (5)ACD/BCF (pH 5.5): 29.91; (6)ACD/BCF (pH 7.4): 29.91; (7)ACD/KOC (pH 5.5): 396.28; (8)ACD/KOC (pH 7.4): 396.28; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 71.06 Å²; (13)Index of Refraction: 1.577; (14)Molar Refractivity: 109.5 cm³; (15)Molar Volume: 330.3 cm³; (16)Polarizability: 43.41×10^-24cm³; (17)Surface Tension: 52.7 dyne/cm; (18)Density: 1.36 g/cm³; (19)Flash Point: 303.7 °C; (20)Enthalpy of Vaporization: 99.42 kJ/mol; (21)Boiling Point: 578.5 °C at 760 mmHg; (22)Vapour Pressure: 8.57E-16 mmHg at 25°C.

3. Structure Descriptors of Fluocinolone acetonide

You could convert the following datas into the molecular structure:
(1)SMILES: O=C\1\C=C5/[C@@](/C=C/1)(C)[C@]2(F)[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F
(2)InChI: InChI=1/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1
(3)InChIKey: FEBLZLNTKCEFIT-VSXGLTOVBO

4. Toxicity of Fluocinolone acetonide

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	> 3170mg/kg (3170mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse	LD50	intraperitoneal	103mg/kg (103mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse	LD50	oral	> 4gm/kg (4000mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse	LD50	subcutaneous	200mg/kg (200mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
rat	LD50	intraperitoneal	42mg/kg (42mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
rat	LD50	oral	> 4gm/kg (4000mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.
rat	LD50	subcutaneous	108mg/kg (108mg/kg)		Drugs in Japan Vol. 6, Pg. 694, 1982.

5. Safety Information of Fluocinolone acetonide

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful by inhalation, in contact with skin and if swallowed. What's more, there's limited evidence of a carcinogenic effect. Therefore, you had better take the following instructions: Do not breathe the dust; Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.