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Fluoroacetic acid

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Name

Fluoroacetic acid

EINECS 205-631-7
CAS No. 144-49-0 Density 1.266 g/cm3
PSA 37.30000 LogP 0.04050
Solubility 50mg/L(20 oC) Melting Point 33 °C
Formula C2H3FO2 Boiling Point 167.903 °C at 760 mmHg
Molecular Weight 78.043 Flash Point 55.346 °C
Transport Information UN 2642 Appearance N/A
Safety 26-36/37/39-45-61-22-20 Risk Codes 20/21/22-35-50-28
Molecular Structure Molecular Structure of 144-49-0 (Fluoroacetic acid) Hazard Symbols VeryT+,DangerousN
Synonyms

Aceticacid, fluoro- (8CI,9CI);Cymonic acid;Fluoroethanoic acid;Gifblaar poison;HFA;Monofluoroacetic acid;a-Fluoroacetic acid;

Article Data 42

Fluoroacetic acid Chemical Properties

IUPAC Name: 2-Fluoroacetic acid
The MF of 2-Fluoroacetic acid (CAS NO.144-49-0) is C2H3FO2.

                         
The MW of 2-Fluoroacetic acid (CAS NO.144-49-0) is 78.04.
Synonyms of 2-Fluoroacetic acid (CAS NO.144-49-0): a-Fluoroacetic acid ; Alpha-fluoroacetic acid ; Monofluoressigsaure ; Acetic acid, fluoro-
Apperance: A colorless crystalline solid
Index of Refraction: 1.343 
Product Categories: HFA
EINECS: 205-631-7
Density: 1.266 g/ml 
Flash Point: 55.3 °C
Boiling Point: 167.9 °C
Melting Point: 33 °C

Fluoroacetic acid Uses

   2-Fluoroacetic acid (CAS NO.144-49-0) is used to make other chemicals.

Fluoroacetic acid Toxicity Data With Reference

1.    

orl-rat LD50:4680 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 13 (1968),189.
2.    

orl-mus LD50:7 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 13 (1968),189.
3.    

ipr-mus LD50:6600 µg/kg

    JOCEAH    Journal of Organic Chemistry. 21 (1956),883.
4.    

scu-mus LD50:281 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 95 (1949),62.
5.    

ivn-mus LD50:13 mg/kg

    CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03014 .
6.    

ivn-rbt LD50:250 µg/kg

    NATUAS    Nature. 158 (1946),382.
7.    

orl-gpg LD50:468 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 13 (1968),189.

Fluoroacetic acid Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Fluoroacetic acid Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Affects the human central nervous system, causing convulsions and ventricular fibrillation. When heated to decomposition it emits toxic fumes of F and Na2O. See also SODIUM FLUOROACETATE.Safety information of 2-Fluoroacetic acid (CAS NO.144-49-0):
Hazard Codes  VeryT+,DangerousN
Risk Statements 
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
35 Causes severe burns
50 Very Toxic to aquatic organisms
28 Very Toxic if swallowed
Safety Statements 
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61 Avoid release to the environment. Refer to special instructions safety data sheet
22 Do not breathe dust
20 When using, do not eat or drink
RIDADR  2642
HazardClass  6.1(a)
PackingGroup  I

Fluoroacetic acid Standards and Recommendations

DOT Classification:  6.1; Label: Poison

Fluoroacetic acid Specification

Fluoroacetic acid is a halogenated carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Fluoroacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.