COMMUNICATIONS
Synthesis of Diverse Azolo[c]quinazolines
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General Procedure for the Aerobic Oxidative
Coupling of a-(2-Aminophenyl)azoles and
Isocyanides
A 10-mL round-bottom flask equipped with a reflux con-
denser was charged with the corresponding a-(2-aminophe-
nyl)azole (0.5 mmol), Pd catalyst and 4ꢂ MS (150 mg).
Next, 2-methyltetrahydrofuran (2.5 mL) and the isocyanide
(0.6 mmol) were added and the reaction mixture was stirred
at 758C for the indicated time under an air atmosphere. The
mixture was cooled, filtered through Celite (DCM) and pu-
rified by flash chromatography (SiO2). Note: some of the
solvent evaporated during the course of most reactions, es-
pecially with longer reaction times. It is possible this affect-
ed the reaction outcome.
´ ˇ
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Acknowledgements
This work was financially supported by The Netherlands Or-
ganization for Scientific Research (NWO) by means of
a TOP grant to R.V.A.O., and by the Hercules Foundation.
We thank Elwin Janssen for technical assistance, Sanne
Bouwman for HR-MS measurements, and Dr. Andreas W.
Ehlers for NMR spectroscopic measurements. We thank Prof.
Dr. Matthias Zeller (Youngstown State University) for the
collection of the X-ray data set. The diffractometer was
funded by NSF (grant 0087210), Ohio Board of Regents
(grant CAP-491), and YSU.
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