Tetrahedron p. 5403 - 5414 (1988)
Update date:2022-07-29
Topics:
Bretschneider, Thomas
Miltz, Wolfgang
Muenster, Peter
Steglich, Wolfgang
The reaction of N-acylamino-2-bromoacetates 2 ( via N-acylimino acetates 3 ) with higher order mixed cuprates, trimethylsilyl enol ethers and β-dicarbonyl compounds leads to a variety of α-amino acid derivatives.Their conversion into the free amino acids can be conveniently carried out by the use of t-butyl protection.In case of the N-acetyl compounds cleavage of the protecting group and optical resolution can be achieved in one step hog renal acylase.
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Doi:10.1055/s-1988-27558
(1988)Doi:10.1002/chem.200901617
(2009)Doi:10.3762/bjoc.5.71
(2009)Doi:10.1016/j.bmcl.2009.11.066
(2010)Doi:10.1021/cc900125a
(2010)Doi:10.1021/ja907462h
(2009)