J. Xie et al. / Bioorg. Med. Chem. Lett. 21 (2011) 4306–4309
4309
Figure 1. Inhibitory activity assays of the compound 4, 9–36 at 100 lM against the PTP1B.
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Table 3
Inhibitory activity against PTP1B of compounds 29, 35,
and 36a
b
Compound
IC50
(
lM)
29
35
36
16.36
14.93
13.92
BPV(phen)
127.90
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1985, 48, 47.
a
Assays were performed in 100% DMSO.
The IC50 values represent the average of three
b
independent experiments.
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H.; Tsuda, M.; Kobayashi, J. J. Nat. Prod. 1998, 61, 693; (c) Eder, C.; Proksch, P.;
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Acknowledgments
We acknowledge the National High Technology Research and
Development Program of China (863 Program) (No. 2006AA
09Z446) and the National Natural Science Foundation of China
(Nos. 20872182, 20802095) for their financial support.
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Supplementary data
Supplementary data associated with this article can be found, in
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