Bioorganic and Medicinal Chemistry Letters p. 3521 - 3525 (2014)
Update date:2022-08-04
Topics: Ligands Receptor Chemical compound Protein synthesis RNA Hepatitis C virus Internal ribosome entry site (IRES) 2-Aminobenzoxazole
Rynearson, Kevin D.
Charrette, Brian
Gabriel, Christopher
Moreno, Jesus
Boerneke, Mark A.
Dibrov, Sergey M.
Hermann, Thomas
2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
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