Carbohydrate Research p. 33 - 48 (1989)
Update date:2022-07-29
Topics:
Kinzy, Willy
Schmidt, Richard R.
Mucin-type O-glycopeptides containing the β-D-GlcpNAc-(1->3)-D-GalpNAc core unit were synthesised from 2-azido-2-deoxy-D-glucose, 2-azido-2-deoxy-D-galactose, 2-azido-2-deoxylactose, and L-serine precursors, using the trichloroacetimidate method.Thus, β-D-GlcpNAc-(1->3)-α-D-GalpNAc-(1->3)-Ser (1) and a derivative of β-D-Galp-(1->4)-β-D-GlcpNAc-(1->6)-<β-D-GlcpNAc-(1->3)>-α-D-GalpNAc-(1->3)-Ser (2) were obtained.A precursor of 1 having HO-4,6 of the 2-azido-2-deoxy-D-galactose residue unsubstituted was a valuable intermediate for the synthesis of 2 due to regioselective glycosylation at O-6.Regioselectivity in this reaction was not observed for precursors having a tert-butyldimethylsilyl group at O-1 instead of a protected L-serine moiety.
View MoreAnyang Double Circle Auxiliary CO.,LTD
Contact:0086-134 6082 4403
Address:dongfeng road, anyang city, henan province,china
SHANGHAI SYSTEAM BIOCHEM CO., LTD
website:http://www.systeambc.com
Contact:86-021-58380978
Address:Building 87,Lane 669, Dong Jing Road Shanghai,P.R.China
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Jiangxi Lanqi Fine Chemical S&T Co., Ltd.
Contact:+86-21-64891143
Address:XinJiShan Industrial Area, Zhangshu City, JiangXi Province, China
Frapp's Chemical (NFTZ) Co.,Ltd
Contact:+86-576-86137892
Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Doi:10.1016/j.bmcl.2010.11.012
(2011)Doi:10.1002/ardp.201000061
(2010)Doi:10.1016/j.saa.2010.12.056
(2011)Doi:10.1021/om101065z
(2011)Doi:10.1016/j.ica.2010.11.023
(2011)Doi:10.1016/S0040-4039(01)80554-2
(1989)