Synthesis p. 1057 - 1058 (1990)
Update date:2022-07-29
Topics:
Alberola
Alvarez
Andres
Gonzalez
Pedrosa
2-Substituted 3-benzyl-1,3-oxazinanes react with the Reformatsky reagent derived from ethyl 2-bromoacetate and zinc, using very mild conditions (0°C, 1 h) leading regioselectively to 3-substituted ethyl 3-[(3-hydroxypropyl)benzylamino]propanoates in high yield.
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Doi:10.1021/jo00006a059
(1991)Doi:10.1248/cpb.39.626
(1991)Doi:10.1002/zaac.19663440103
(1966)Doi:10.1021/jo00005a037
(1991)Doi:10.1039/c1jm11242b
(2011)Doi:10.1021/ol201870h
(2011)