K. Mitachi et al. / Bioorg. Med. Chem. Lett. 22 (2012) 4536–4539
4539
Figure 4. Antimalarial activity and cytotoxicity of compounds 1–54 and 1a–7p0.
ring. Gratifyingly, this new compound library provided compound
References and notes
7c0, whose antimalarial activity was the most promising lead of all
our compounds (EC50: 0.800 nM) against both K1 and 3D7. This
compound also showed no considerable cytotoxicity at the tested
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We gratefully acknowledge the financial support of the Ameri-
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Supplementary data
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Supplementary data associated with this article can be found, in