ACS Catalysis
Letter
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(9) For a Rh-catalyzed hydroacylation of N-tethered aldehyde-
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12466.
benzoin reaction with N-tethered substrates. Various substituted
dihydroquinolinone derivatives were obtained with a quaternary
carbon stereocenter in moderate to good yields and excellent ee.
The mild reaction conditions utilizing a weak base NaOAc are
critical for minimizing the aldol side reaction.
ASSOCIATED CONTENT
* Supporting Information
■
S
Experimental procedures and characterization of the products.
This material is available free of charge via the Internet at
AUTHOR INFORMATION
Corresponding Author
■
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
We thank the National Basic Research Program of China
(973 Program 2009CB825300) and National Natural Science
Foundation of China (20972177, 21025209, 21121062) for
generous financial support.
(12) See the Supporting Information for details.
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dx.doi.org/10.1021/cs4000014 | ACS Catal. 2013, 3, 622−624