Journal of Medicinal Chemistry p. 497 - 503 (1993)
Update date:2022-08-03
Topics:
Flouzat, Christine
Bresson, Yvette
Mattio, Anny
Bonnet, Jacqueline
Guillaumet, Gerald
A series of 3-(aminoalkyl)- and 3-<(4-aryl-1-piperazinyl)alkyl>oxazolo<4,5-b>pyridin-2(3H)-ones were prepared from their respective oxazolo<4,5-b>pyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.
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Doi:10.1021/om00028a025
(1993)Doi:10.1071/CH13244
(2013)Doi:10.1016/j.ica.2013.07.039
(2013)Doi:10.1016/j.bmcl.2013.09.001
(2013)Doi:10.1039/c39920001762
(1992)Doi:10.1021/jo01068a023
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