Journal of Medicinal Chemistry p. 512 - 518 (1994)
Update date:2022-09-26
Topics:
Ducharme, Yves
Brideau, Christine
Dube, Daniel
Chan, Chi-Chung
Falgueyret, Jean-Pierre
et al.
Combinations of structural elements found in (methoxyalkyl)thiazole 1a and methoxytetrahydropyran 2a with a naphthalenic lignan lactone produce the potent 5-lipoxygenase (5-LO) inhibitors 3 and 4.While the nature of link Y-Z has a major effect on the in v
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