SPECIAL TOPIC
Synthesis of a-Fluoro Ketones
2607
1H NMR (400 MHz, CDCl3): d = 8.05 (s, 4 H), 5.67(dq, 1JH,F = 48.4,
Hz, J = 6.8 Hz, 2 H), 1.65 (dd, 2JH,F = 24.1 Hz, J = 6.8 Hz, 6 H).
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2
13C NMR (125 MHz, CDCl3): d = 196.7 (d, JC,F = 20.7 Hz, 2 C),
137.8 (d, 3JC,F = 1.7 Hz, 2 C), 129.3 (d, 4JC,F = 4.1 Hz, 4 C), 90.7 (d,
1JC,F = 180.6 Hz, 2 C), 18.1 (d, 2JC,F = 22.5 Hz, 2 C).
19F NMR (376.4 MHz, CDCl3): d = –181.3.
HRMS-ESI: m/z [M + Na]+ calcd for C12H12F2O2 + Na: 249.0698;
found: 249.0703.
Supporting Information for this article is available online at
Acknowledgment
(9) Mizuno, A.; Kusama, H.; Iwasawa, N. Chem. Eur. J. 2010,
16, 8248.
Financial support from the Swedish Research council (vetenskaps-
rådet), the Wenner–Gren Foundation, the Knut and Alice Wallen-
berg Foundation, and the Berzelius center EXSELENT is gratefully
acknowledged.
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Chem. Eur. J. 2008, 14, 10547. (b) Ahlsten, N.; Martín-
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Synthesis 2011, No. 16, 2600–2608 © Thieme Stuttgart · New York