Chemistry - A European Journal p. 11320 - 11324 (2015)
Update date:2022-08-03
Topics:
Maity, Soham
Agasti, Soumitra
Earsad, Arif Mahammad
Hazra, Avijit
Maiti, Debabrata
Insertion of unsaturated systems such as alkynes and olefins into unactivated sp3 C-H bonds remains an unexplored problem. We herein address this issue by successfully incorporating a wide variety of functionalized alkynes and electron-deficient olefins into the unactivated sp3 C-H bond of pivalic acid derivatives with excellent syn- and linear- selectivity. A strongly chelating 8-aminoquinoline directing group proved beneficial for these insertion reactions, while an air-stable and inexpensive NiII salt has been employed as the active catalyst. Unactive duty: A wide variety of functionalized alkynes and electron-deficient olefins has been incorporated into the unactivated sp3 C-H bond of pivalic acid derivatives with excellent syn and linear selectivity. A strongly chelating 8-aminoquinoline directing group proved beneficial for these insertion reactions, while an air-stable and inexpensive NiII salt was used as the active catalyst. EWG=electron-withdrawing group.
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