Bioorganic and Medicinal Chemistry Letters p. 357 - 360 (1996)
Update date:2022-08-03
Topics:
Poulsen, Sally-Ann
Quinn, Ronald J.
Following the demonstration that substitution of 1-phenylpyrazolo[3,4-d]pyrimidines at C6 with thioethers containing amide moieties could effect adenosine A1 and A(2a) receptor selectivity, two compounds with high A1 selectivity have been obtained by a combined C4, C6 substitution. This further demonstrates that distal moieties at C6 can effect selectivity and that C4 substituents have an important role.
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